Frequency and aetiology of hypercalcaemia

Archives of Disease in Childhood
J D McNeillyS F Ahmed

Abstract

Hypercalcaemia is rare in children and may present with characteristic signs/symptoms or coincidentally following investigations for a variety of non-specific conditions. The aetiologies of childhood hypercalcaemia are diverse. Untreated sustained hypercalcaemia has serious clinical consequences. However there is limited data regarding the true frequency and aetiologies of childhood hypercalcaemia. To determine the frequency of severe childhood hypercalcaemia in routine clinical practice. The laboratory database was searched for all children (0-17 years) with severe hypercalcaemia defined as non-adjusted ≥2.90 mmol/L from 2007-2012. Hypercalcaemia was categorised as either transient (1 day) or sustained (≥2 consecutive days). Retrospective analysis of all cases of sustained severe hypercalcaemia was performed to identify the underlying aetiology. Over the 5 year period, 206 children were identified as severely hypercalcaemic ≥2.90 mmol/L (0.3% all 61 380 calcium requests). Of these 131 (63.3%) children were classified as having sustained hypercalcaemia. The frequency of severe hypercalcaemia was highest in neonates (42% of sustained cases) and was inversely related to age. Sepsis was the most common aetiology (24%), particularl...Continue Reading

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Citations

Mar 17, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Kinyas KartalMehmet Uludag
Sep 16, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Victoria J StokesRajesh V Thakker
Dec 22, 2017·Journal of the Endocrine Society·Melissa J SchoelwerErik A Imel
Sep 3, 2020·Annals of Pediatric Endocrinology & Metabolism·Youngseok SeoHo-Seong Kim
Aug 31, 2019·Case Reports in Endocrinology·Ambreen SonawallaEmir Tas
Jul 9, 2021·Italian Journal of Pediatrics·Nicola ImprodaAngelo Izzo

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