Frequency and amplitude modulation of resting-state fMRI signals and their functional relevance in normal aging

Neurobiology of Aging
Albert C YangNorden E Huang

Abstract

The intrinsic composition and functional relevance of resting-state blood oxygen level-dependent signals are fundamental in research using functional magnetic resonance imaging (fMRI). Using the Hilbert-Huang Transform to estimate high-resolution time-frequency spectra, we investigated the instantaneous frequency and amplitude modulation of resting-state fMRI signals, as well as their functional relevance in a large normal-aging cohort (n = 420, age = 21-89 years). We evaluated the cognitive function of each participant and recorded respiratory signals during fMRI scans. The results showed that the Hilbert-Huang Transform effectively categorized resting-state fMRI power spectra into high (0.087-0.2 Hz), low (0.045-0.087 Hz), and very-low (≤0.045 Hz) frequency bands. The high-frequency power was associated with respiratory activity, and the low-frequency power was associated with cognitive function. Furthermore, within the cognition-related low-frequency band (0.045-0.087 Hz), we discovered that aging was associated with the increased frequency modulation and reduced amplitude modulation of the resting-state fMRI signal. These aging-related changes in frequency and amplitude modulation of resting-state fMRI signals were unaccoun...Continue Reading

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