Abstract
In order to analyze the development of antibody diversity in which the genes coding for the antigen-specific cells we have compared the binding of diverse antigens by cells in the fetal, neonatal, and adult mouse. Although the numbers of antigen-binding cells present in fetuses and young animals were smaller than in adults, no restriction could be detected in the varity of specificities expressed in the fetuses, either with respect to the kinds of antigens bound, or to the range of avidities of binding. Cells specific for each of the 11 antigens tested could be detected in the fetus only in the last 4 days before birth, at which time they appeared both in the liver and in the spleen. In all cases, these cells disappeared both in the liver and in the spleen. In all cases, these cells disappeared from the liver within a day of birth, but continued to increase in number in the spleen until adulthood...
References
May 1, 1975·The Journal of Experimental Medicine·N R Klinman, J L Press
Jan 1, 1975·The Journal of Experimental Medicine·E S VitettaJ W Uhr
Jan 1, 1975·Transplantation Reviews·F MelchersR A Phillips
Dec 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·U Rutishauser, G M Edelman
Feb 1, 1973·European Journal of Immunology·B E Elliott, J S Haskill
Nov 1, 1974·The Journal of Experimental Medicine·E A Goidl, G W Siskind
Jul 25, 1970·Nature·J A Gally, G M Edelman
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·U RutishauserG M Edelman
May 1, 1974·The Journal of Experimental Medicine·M C GelfandW E Paul
Mar 1, 1974·European Journal of Immunology·J L Press, N R Klinman
Aug 1, 1972·European Journal of Immunology·O SjöbergG Möller
Sep 1, 1973·The Journal of Experimental Medicine·P G SpearG M Edelman
Feb 1, 1974·The Journal of Experimental Medicine·P G Spear, G M Edelman
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·U RutishauserG M Edelman
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
May 1, 1963·The Journal of Experimental Medicine·A M SILVERSTEINR J LUKES
Sep 1, 1964·The Journal of Experimental Medicine·A E REIF, J M ALLEN
Jan 1, 1971·European Journal of Immunology·N K Jerne
Citations
May 1, 1979·Cellular Immunology·J P McKearn, J Quintáns
Jun 1, 1978·Immunochemistry·B B Fuchs, J V Spirande
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C BruynsJ Urbain
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D R KaplanH Köhler
Jun 1, 1976·The Journal of Experimental Medicine·E A GoidlG W Siskind
Jul 1, 1976·The Journal of Experimental Medicine·P D'EustachioG M Edelman
Jul 1, 1976·The Journal of Experimental Medicine·P M LydyardM D Cooper
Aug 1, 1977·The Journal of Experimental Medicine·J E CohenG M Edelman
Oct 1, 1977·The Journal of Experimental Medicine·N H SigalN R Klinman
Feb 1, 1980·The Journal of Experimental Medicine·J M Teale, T E Mandel
Jan 1, 1979·Journal of Clinical Pathology. Supplement (Royal College of Pathologists)·J J Owen
Aug 1, 1977·Biulleten' eksperimental'noĭ biologii i meditsiny·I V Spirande, B B Fuks
May 27, 2020·ELife·Brady T HickersonBrian B Gowen
Jul 1, 1976·European Journal of Immunology·J G Howard, C Hale
Jun 1, 1976·European Journal of Immunology·A Skowron-Cendrzak, W Ptak