Frequency and characteristics of disease flares in ankylosing spondylitis.

Rheumatology
Roxanne CookseyStefan Siebert

Abstract

To examine the characteristics and frequency of disease flares in a cohort of people with AS. A prospective data set from a randomized controlled trial (RCT) of a probiotic treatment/placebo was utilized to examine disease flares in 134 people with AS. Disease flares were defined as either minor/localized flares (pain/swelling localized to one area with fatigue and stiffness) or major/generalized flares (generalized pain, hot burning joints, muscle spasm, fever, sweating, extreme fatigue and stiffness). Results. One hundred and thirty-four people were followed up for 1216 person follow-up weeks and there were 71.4 flares per 100 person-weeks. Of these, 12 were major/generalized flares and 59.4 were minor/localized flares. People who experienced at least one major/generalized flare during the study period had worse disease during flare-free periods in terms of disease activity, impaired function, self-reported night pain and iritis compared with those who did not experience any major/generalized flares during the study. Major/generalized flares lasted for an average of 2.4 weeks (s.d. 2.7), and were preceded by and followed by a minor/localized flare in 92% (55/60) of cases. Seventy per cent of people with AS felt they had a fla...Continue Reading

Citations

Sep 3, 2010·BMC Musculoskeletal Disorders·Mark D AtkinsonRonan A Lyons
Jan 27, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Marie Godfrin-ValnetDaniel Wendling
Mar 17, 2016·Annals of the Rheumatic Diseases·Daniel Wendling, Clément Prati
Aug 26, 2016·Rheumatology·Louise HamiltonUNKNOWN BSR and BHPR Standards, Guidelines and Audit Working Group
Mar 13, 2018·Rheumatology·Mohammad H DerakhshanUNKNOWN NASS and BRITSpA investigators
Dec 17, 2016·The Journal of Rheumatology·Charlotte JacqueminLaure Gossec
Jul 15, 2021·Dysphagia·Esmail Abdulahi AhmedÖmer Kuru

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