PMID: 16623259Apr 21, 2006Paper

Frequency and characteristics of hepatitis B infection in children with malignant diseases

Srpski arhiv za celokupno lekarstvo
Nada JovanovićJelena Lazić

Abstract

Hepatitis B, a complication of blood transfusion or other means of transmission, occurs with variable frequency in children with malignant diseases. The objective of this study was to determine the frequency of hepatitis B virus infection in children with malignant diseases, to investigate the clinical course of the illness, and to analyse the influence of hepatitis on cytotoxic treatment. The study included children diagnosed and treated for malignant diseases at the University Children's Hospital in Belgrade from 1997 to 2003. HBs Ag was analysed in all patients who had elevated transaminases of twice normal value, in children who had icterus, and in one group of patients treated routinely after 2001 before, during, and after therapy. RESULTS A total of 137 male and 107 female children who had malignancies were treated. From 113 children who were evaluated for the presence of HBs Ag at the beginning of treatment, 2 (1.7%) were HBsAg+. In this group of patients HBsAg was tested in 58 (51%) children during and after chemotherapy, and HBsAg was discovered in 17 (29%) of them. Of 123 children, in whom HBsAg was not tested at the beginning of their illness, 36 (55%) out of 66 (51%) tested patients were HBsAg+. No statistical diffe...Continue Reading

References

Dec 6, 2001·The Pediatric Infectious Disease Journal·J StyczynskiA Kurylak
May 3, 2002·Clinical and Diagnostic Laboratory Immunology·Kirsten VisonáM Mercedes Somarriba
Oct 24, 2002·Blood·Jean-Pierre AllainOhene Opare-Sem
Dec 4, 2002·Medical and Pediatric Oncology·Betül SevinirMelda Sinirtas
Dec 7, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Herwig LacknerChristian Urban

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