PMID: 8593527Sep 1, 1995Paper

Frequency and characteristics of post-transfusion hepatitis in Greece with emphasis on hepatitis C: comparing second- and third-generation assays

Transfusion Medicine
K MakrisA Maniatis

Abstract

In order to evaluate the role of hepatitis C virus (HCV) in post-transfusion hepatitis (PTH) in Greece we prospectively followed 143 transfusion recipients, receiving 790 units of blood and/or products from 789 donors, between October 1989 and December 1991. The mean number of units transfused per patient was 5.52. PTH was observed in 18 patients (12.59%). One patient (0.70%) developed hepatitis B, in four (2.80%) hepatitis could be attributed to CMV infection, 10 (6.99%) developed hepatitis C and three (2.10%) showed only raised alanine aminotransferase (ALT) levels. The risk of PTH per 1000 units transfused was 22.8. The patient who developed hepatitis B (PTH-B) was transfused with four units, one of which was positive for anti-HBc and anti-HBe. Seven of the 10 patients (70%) who developed hepatitis C (PTH-C) were transfused with at least one unit seropositive in the anti-HCV screening with 2nd-generation tests (ELISA-2 and RIBA-2), whereas 9/10 of PTH-C cases (90%) were transfused with at least one unit positive in 3rd-generation assays. Of the three patients who showed only ALT elevation, none was transfused with anti-HCV seropositive blood, although one of them was transfused with at least one unit with elevated ALT levels...Continue Reading

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Citations

Feb 7, 2001·Clinical Microbiology Reviews·N N Zein
Sep 19, 2001·Mayo Clinic Proceedings·J J Germer, N N Zein
Apr 2, 2005·Alimentary Pharmacology & Therapeutics·F FabriziP Martin
Sep 26, 2003·Transfusion·Leslie H ToblerMichael P Busch
Jan 24, 2003·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·L LiuZ Xu
Jan 23, 2015·Lab on a Chip·Robert LinAmy E Herr
Dec 17, 1997·Journal of Clinical Microbiology·J A NevilleP Simmonds

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