Frequency and characteristics of TBII-seronegative patients in a population with untreated Graves' hyperthyroidism: a prospective study

Clinical Endocrinology
Xander G VosWilmar M Wiersinga

Abstract

It is claimed that second generation thyrotropin-binding inhibitory immunoglobulin (TBII) assays have a very high sensitivity for the diagnosis of Graves' hyperthyroidism (GH). However, studies evaluating the accuracy of TBII have been retrospective in nature and/or GH had not been diagnosed independently of TBII. The aim of the present study, therefore, was to prospectively evaluate the frequency and characteristics of TBII-seronegative patients in a population of untreated GH diagnosed independent of serum TBII. Prospective multicentre observational study. A total of 259 consecutive untreated patients with a first episode of GH, diagnosed independent of serum TBII. TBII levels were measured by second generation assay and correlated to thyroid function, clinical characteristics and exposure to environmental factors. Serum TBII was positive in 245 (94.6%) patients and negative (< 2 IU/l) in 14 (5.4%) patients. TBII-seronegative patients had lower fT4 (median 42.5 vs. 53.9 pmol/l, P = 0.02), T3 (median 3.55 vs. 4.90 nmol/l, P < 0.01) and fT3-index (median 4.30 vs. 6.27, P < 0.01) compared to TBII-seropositive patients. None of the TBII-seronegative patients had TSH-receptor activating mutations, Graves' orbitopathy or pretibial ...Continue Reading

References

Feb 1, 1988·Archives of Internal Medicine·I KleinG S Levey
Oct 1, 1982·Clinical Endocrinology·G Shewring, B R Smith
Jun 1, 1996·Journal of Endocrinological Investigation·S L WuC C Chang
Jan 27, 1999·The Journal of Clinical Endocrinology and Metabolism·S CostagliolaK H Usadel
Nov 9, 2000·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M SchottJ Seissler
Dec 29, 2000·Thyroid : Official Journal of the American Thyroid Association·P LaurbergL Ovesen
Feb 7, 2001·The Journal of Clinical Endocrinology and Metabolism·T H BrixL Hegedüs
May 11, 2004·European Journal of Endocrinology·Mark F PrummelWilmar M Wiersinga
Oct 29, 2005·American Journal of Clinical Dermatology·Vahab Fatourechi
Feb 16, 2006·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J Paunkovic, N Paunkovic
Jul 13, 2006·The Journal of Clinical Endocrinology and Metabolism·Anja K EcksteinNils G Morgenthaler
Sep 14, 2006·The Journal of Clinical Endocrinology and Metabolism·N ManjiJ A Franklyn

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Citations

Apr 10, 2009·Thyroid : Official Journal of the American Thyroid Association·Thomas LinckeRalf Paschke
Dec 31, 2010·Thyroid : Official Journal of the American Thyroid Association·Laura ElbersWilmar Wiersinga
Oct 12, 2010·European Journal of Endocrinology·A HébrantJ Leclère
Sep 13, 2012·European Journal of Endocrinology·Xander G VosWilmar M Wiersinga
Apr 23, 2011·Thyroid : Official Journal of the American Thyroid Association·Rebecca S Bahn ChairUNKNOWN American Association of Clinical Endocrinologists
Nov 21, 2012·La Presse médicale·Jacques Orgiazzi
May 29, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Seethalakshmi Iyer, Rebecca Bahn
May 17, 2011·European Journal of Internal Medicine·David C Matthews, Akheel A Syed
Jun 27, 2015·Cytokine·Ewelina MotylewskaHenryk Stępień
Apr 28, 2011·Clinical Endocrinology·A TheodorakiM P J Vanderpump
Aug 16, 2016·Thyroid : Official Journal of the American Thyroid Association·Douglas S RossMartin A Walter
Dec 6, 2018·The Journal of Clinical Endocrinology and Metabolism·Arjola BanoSalman Razvi
Mar 30, 2013·The Journal of Clinical Endocrinology and Metabolism·Giuseppe Barbesino, Yaron Tomer
Mar 18, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Chhavi ChadhaCary N Mariash
Jun 28, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Rebecca S BahnUNKNOWN American Association of Clinical Endocrinologists
Sep 9, 2018·Journal of Endocrinological Investigation·S Seo, M Sánchez Robledo
May 22, 2016·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Simona GaberščekSergej Hojker
May 18, 2013·Arquivos brasileiros de endocrinologia e metabologia·Ana Luiza MaiaUNKNOWN Brazilian Society of Endocrinology and Metabolism

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