PMID: 8610650Apr 1, 1996Paper

Frequency and clinical implications of delayed nausea and delayed emesis

American Journal of Clinical Oncology
G R MorrowS N Rosenthal

Abstract

Studies of the adverse effects of cancer chemotherapy often do not distinguish between delayed and persistent nausea and emesis. Although persistent nausea is simply acute nausea that continues beyond the treatment day, postchemotherapy delayed nausea and delayed vomiting first develop after an initial 24 h free of these symptoms. To access its occurrence in clinical practice, we conducted a structured examination of chemotherapy-induced delayed nausea and emesis in consecutive chemotherapy patients unselected for diagnosis, chemotherapy, or antiemetic usage. Three hundred twenty-seven consecutive with histologically confirmed cancer were followed through three consecutive chemotherapy treatments at three geographically separate institutions. Patient-reported assessments of nausea and emesis were made for each 6-h period over 3 days after chemotherapy. One in three patients developed delayed nausea and one in four incurred delayed emesis. Of >950 chemotherapy treatments assessed, approximately 1 in 6 were characterized by delayed nausea and 1 in 9 by delayed vomiting. We conclude that nausea and emesis that first begin >24 h after chemotherapy are a significant clinical concern. Patients receiving cancer chemotherapy without be...Continue Reading

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Citations

Jul 28, 2004·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Agnes GlausRobert Deuson
Feb 16, 2005·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jennifer S YatesLauren K Colman
Sep 3, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·David S EttingerAteesha F Mohamed
Mar 31, 2012·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·P Fernández-OrtegaA Llombart-Cussac
May 11, 2011·Journal of Palliative Medicine·Jason M JonesCharles L Loprinzi
Nov 15, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lorenzo CohenHenry Hu
Apr 7, 2016·The New England Journal of Medicine·Rudolph M Navari, Matti Aapro
May 16, 2002·American Journal of Obstetrics and Gynecology·Thomas Murphy Goodwin
Dec 13, 2005·Expert Review of Anticancer Therapy·Enrique Aranda AguilarSalvador Martin-Algarra
Mar 3, 2007·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Deborah L Robinson, Barbara A Carr
Jan 1, 2003·Expert Review of Neurotherapeutics·Joshua L Roffman, William F Pirl
Feb 16, 2002·Clinical Nursing Research·Nancy R Reynolds, Judith L Neidig
Mar 29, 2005·Experimental Biology and Medicine·Ester FrideTim C Kirkham
Jun 29, 2017·Journal of Gynecologic Oncology·Ken Ichirou Morishige

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