Frequency and clinical significance of a variety of autoantibodies in patients with definite infective endocarditis

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
Rafael BojalilLuis M Amezcua-Guerra

Abstract

Patients with infective endocarditis (IE) may present rheumatic manifestations concurrent with autoantibodies with low specificity, thus increasing misdiagnosis. Frequency of autoantibodies with high specificity remains unknown. Nineteen patients with definite IE were studied for low specificity (rheumatoid factor [RF], antinuclear antibodies, anti-Ro/SSA, anti-La/SSB, anti-ribonucleoproteins (anti-RNP) anticardiolipin [aCL], and anti-β2 glycoprotein 1) and high specificity (anti-cyclic citrullinated peptides [anti-CCPs], anti-double-stranded DNA, anti-Sm, anti-Scl70, and anticentromere) antibodies. Frequency of RF was 68%; antinuclear antibodies, 47%; aCL/IgG, 58%; aCL/IgM, 47%; anti-β2 glycoprotein 1/IgG, 5%; and anti-Ro/SSA, 5%. Three patients had antiphospholipid syndrome-related antibodies in high titers, one of them also having pulmonary embolism. Except for anti-CCP (1 patient), other highly specific antibodies were absent.Rheumatoid factor of 100 UI/mL or greater and multifocal endocarditis were independently associated with in-hospital mortality. Clinicians should need to be aware about the common presence of a variety of antibodies with low specificity but also the exceptional occurrence of anti-CCP antibodies in IE. ...Continue Reading

References

Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S LiG R Corey
Feb 24, 2001·Medicine·C González-JuanateyJ R González-Juanatey
Mar 17, 2006·Annals of the Rheumatic Diseases·D MakrygiannakisA I Catrina
Aug 29, 2006·Arthritis Research & Therapy·Luis M Amezcua-GuerraRafael Bojalil
Apr 24, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Alexandra M Tiliakos, Nicholas A Tiliakos
Mar 11, 2009·Archives of Internal Medicine·David R MurdochUNKNOWN International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators
Aug 6, 2010·Clinical Rheumatology·Isabella Lima, Mittermayer Santiago

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Citations

Mar 13, 2013·The American Journal of Emergency Medicine·Dimitrios NteliosCharalampos Mandros
Apr 17, 2014·Expert Review of Clinical Immunology·Damian MasedaLeslie J Crofford
Nov 21, 2017·Lupus·P López-MatoG Espinosa
Jan 7, 2018·Heart·Christine Selton-SutyUNKNOWN Endocarditis Team of the University Hospital of Nancy, France
Feb 12, 2017·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C ZaratzianD Raoult
Nov 20, 2019·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Masayoshi TodaYasuhiko Ito

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