Frequency and distribution of DNA uptake signal sequences in the Haemophilus influenzae Rd genome

Science
H O SmithJ C Venter

Abstract

The naturally transformable, Gram-negative bacterium Haemophilus influenzae Rd preferentially takes up DNA of its own species by recognizing a 9-base pair sequence, 5'-AAGTGCGGT, carried in multiple copies in its chromosome. With the availability of the complete genome sequence, 1465 copies of the 9-base pair uptake site have been identified. Alignment of these sites unexpectedly reveals an extended consensus region of 29 base pairs containing the core 9-base pair region and two downstream 6-base pair A/T-rich regions, each spaced about one helix turn apart. Seventeen percent of the sites are in inverted repeat pairs, many of which are located downstream to gene termini and are capable of forming stem-loop structures in messenger RNA that might function as signals for transcription termination.

References

Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·K L Sisco, H O Smith
Oct 1, 1990·Journal of Bacteriology·S H Goodgal, M A Mitchell
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S D Goodman, J J Scocca
May 1, 1974·Journal of Bacteriology·J J ScoccaK C Zoon
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D B DannerS A Narang
Jan 1, 1984·The Journal of Membrane Biology·M E Kahn, H O Smith
Jul 28, 1995·Science·R D FleischmannJ M Merrick
Mar 15, 1994·Experientia·G R Smith

❮ Previous
Next ❯

Citations

Apr 1, 1996·Trends in Genetics : TIG·J M Solomon, A D Grossman
Oct 28, 1998·Molecular Aspects of Medicine·G Del GiudiceR Rappuoli
Nov 1, 1995·Trends in Genetics : TIG·K M Devine, K Wolfe
Nov 14, 1997·Trends in Genetics : TIG·C M TangE R Moxon
May 30, 2001·FEMS Microbiology Letters·J Majewski
Feb 15, 2000·Research in Microbiology·H O SmithS L Salzberg
Feb 15, 2000·Research in Microbiology·M El KarouiA Gruss
Apr 23, 2003·Trends in Microbiology·Jean-Pierre Claverys, Bernard Martin
Oct 6, 1999·Current Opinion in Microbiology·I MoszerA Danchin
Apr 15, 2004·Nature Reviews. Microbiology·Inês Chen, David Dubnau
Apr 27, 2004·Omics : a Journal of Integrative Biology·Anu RaghunathanEugene Kolker
Jan 1, 1997·Microbial & Comparative Genomics·N HandaI Kobayashi
Jan 1, 2009·Genome Biology and Evolution·W A Findlay, R J Redfield
Jun 15, 1996·Nucleic Acids Research·D EspositoJ J Scocca
Nov 1, 1996·Nucleic Acids Research·S KarlinA M Campbell
Jun 10, 1998·Nucleic Acids Research·A Grigoriev
Oct 5, 2002·Nucleic Acids Research·Jan MrázekSamuel Karlin
Feb 13, 2004·Nucleic Acids Research·Tonje DavidsenTone Tønjum
Jun 29, 2005·Nucleic Acids Research·John GladitzGarth D Ehrlich
Jul 4, 2012·Nucleic Acids Research·Joshua Chang MellRosemary J Redfield
Feb 13, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E R MoxonJ C Richards
Jul 23, 1999·Annals of the New York Academy of Sciences·L H Caporale
Jul 23, 1999·Annals of the New York Academy of Sciences·J Mrázek, S Karlin
Apr 23, 2004·Infection and Immunity·Janet R GilsdorfBetsy Foxman
Nov 24, 2006·Journal of Bacteriology·Mario JuhasDerek W Hood

❮ Previous
Next ❯

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