Frequency and genotype of human parvovirus B19 among Iranian patients infected with HIV

Journal of Medical Virology
Kayhan AzadmaneshAmitis Ramezani

Abstract

The human parvovirus B19 (B19) usually causes a subclinical infection in immunocompetent individuals. Whereas immunocompromised individuals such as patients infected with HIV are at risk of persistent anemia due to B19 infection. Only few studies have been carried out on distribution and molecular epidemiology of B19 in Iran. We aimed to determine the frequency and genotype of B19 among Iranian patients infected with HIV. We conducted a survey on 99 HIV patients and 64 healthy controls. IgG and IgM antibodies against B19 were detected by ELISA and B19 DNA was assessed by nested PCR. PCR products were subjected to direct sequencing and classified after phylogenetic analysis. The prevalence of B19 immunoglobulin was 11.1% for IgG and 1% for IgM. B19 DNA was detected in 13.1% of cases. The prevalence of B19 IgG, IgM, and DNA in control group was 25%, 1.6%, and 9.4%, respectively. B19 IgG was significantly lower in HIV group than in normal controls. There was no significant difference regarding anemia between cases and controls. All sequenced B19 isolates belonged to genotype 1A with low genetic diversity. Our findings indicated that in the HAART era, the importance of B19 infections in HIV patients may be limited whereas persisten...Continue Reading

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Citations

Apr 13, 2017·Blood Research·Seyed Ali Mohammad ArabzadehSeyed Hamidreza Monavari
Nov 3, 2017·Journal of Medical Microbiology·Mauro Sebastian PedrantiMaria Pilar Adamo
Sep 15, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Arthur Daniel Rocha AlvesLuciane Almeida Amado
Apr 20, 2021·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Rabab Hasanain Ahmed HasanainHanaa H Gomaa

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