Frequency and imaging features of abdominal immune-related adverse events in metastatic lung cancer patients treated with PD-1 inhibitor

Abdominal Radiology
Francesco AlessandrinoMark M Awad

Abstract

To investigate the frequency and imaging features of radiographically evident abdominal immune-related adverse events (irAEs) in patients with metastatic non-small-cell lung cancer (NSCLC) treated with PD-1 inhibitors. This retrospective study included 137 patients with metastatic NSCLC treated with PD-1 inhibitor nivolumab monotherapy (75 women; median age: 65 years), who had a baseline CT and at least one follow-up abdomen CT during therapy. Baseline and all follow-up abdominal CTs performed for monitoring of nivolumab therapy were reviewed to identify the organ-specific abdominal irAEs including colitis/enteritis, hepatitis, biliary toxicity, pancreatitis, nephritis, sarcoid-like reaction, and pancreatic and adrenal atrophy. Their frequency and imaging features were described. Eighteen (13%) patients had radiologically identified abdominal irAEs (median 2.1 months after starting nivolumab; interquartile range 1.17-5.83 months); 16 patients developed enteritis/colitis (12 pancolitis, two segmental colitis, one enterocolitis, one enteritis), two hepatitis, one adrenalitis. One patient with hepatitis also developed colitis/enteritis. Radiographic abdominal irAE occurred after nivolumab therapy was discontinued in six patients b...Continue Reading

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Citations

Apr 17, 2020·Diagnostics·Vanina VaniEmanuele Neri
Dec 4, 2019·BMJ Case Reports·Iqra IqbalDina Nabwani
Jan 5, 2020·European Radiology Experimental·Clarisse DromainAntonia Digklia
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Sep 21, 2021·The British Journal of Radiology·Nader MohammedZeng Xiong
Aug 1, 2021·Journal of Nuclear Medicine Technology·Jan-Henning SchierzAli Sarikaya

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