Frequency and implications of chromosome 8 and 12 gains in Ewing sarcoma

Cancer Genetics and Cytogenetics
D MauriciJ A Fletcher

Abstract

Ewing sarcoma (ES) is the second most common primary malignant tumor of bone in children and young adolescents. Most ES contain a pathognomonic translocation t(11;22)(q24;q12) that is likely a pivotal event in the tumorigenesis of these neoplasms. Many ES also contain nonrandom, numerical chromosomal aberrations, the most common of which are trisomies 8 and 12. In this study we evaluated the hypothesis that these trisomies might occur during neoplastic progression and might be associated with differences in biologic behavior. We tested this hypothesis using a combined cytogenetic and dual color fluorescence in situ hybridization approach to determine chromosome 8 and 12 copy number in 52 ES. Relative gains, primarily trisomies, of chromosomes 8 and 12 were found in 24 (46%) and 17 (33%) cases, respectively. Trisomy 8 and trisomy 12 were independent events acquired in a flexible order during ES genetic progression. Our preliminary findings also suggest a higher frequency of trisomies 8 and 12 in relapses than in primary tumors. Prospective studies will be required to determine whether either trisomy is prognostic in newly-diagnosed ES.

References

Dec 1, 1992·Cancer Genetics and Cytogenetics·J A Travis, J A Bridge
Jun 1, 1992·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·A V BonniciA C Berry
Aug 1, 1991·Cancer Genetics and Cytogenetics·T DattaA Reichle
Feb 14, 1991·The New England Journal of Medicine·J A FletcherJ M Corson
Feb 1, 1991·Cancer Genetics and Cytogenetics·C SreekantaiahA A Sandberg
Jan 1, 1991·Cytogenetics and Cell Genetics·R E KibbelaarP M Kluin
May 1, 1990·Genes, Chromosomes & Cancer·T PejovicF Mitelman
Mar 1, 1990·Head & Neck·D E SchullerJ M Quivey
Jun 1, 1988·Cancer Genetics and Cytogenetics·F MugneretC Turc-Carel
Jan 20, 1983·The New England Journal of Medicine·J H Spigel
Jun 1, 1994·Genes, Chromosomes & Cancer·P Dal CinH Van den Berghe
May 1, 1995·Cancer Genetics and Cytogenetics·R D CraverY S Kao
Feb 1, 1995·Cancer Genetics and Cytogenetics·J A FletcherJ M Corson
Jun 1, 1993·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·D TaruscioD C Ward
Jan 1, 1993·The American Journal of Surgical Pathology·L P Dehner

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Citations

Sep 5, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Mandeep S TamberJames T Rutka
Mar 26, 2004·Cancer Genetics and Cytogenetics·Anat OhaliRina Zaizov
May 19, 2005·Cancer Genetics and Cytogenetics·Ken M GatterAnne E Rader
Dec 6, 2001·Cancer Genetics and Cytogenetics·P RobertsE Sheridan
Jan 29, 2003·Cancer Genetics and Cytogenetics·Lian ZhaoArmand Glassman
Mar 21, 2003·Cancer Genetics and Cytogenetics·A AmielS Avigad
Dec 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R D RileyI J Lewis
Jun 15, 2010·Oncogene·E C ToomeyS L Lessnick
Feb 17, 2010·Genome Medicine·Heinrich Kovar
Jun 1, 2005·The Lancet Oncology·Boo MessahelKathy Pritchard-Jones
Mar 26, 2011·Sarcoma·Mona S JahromiJoshua D Schiffman
Aug 22, 2000·Cancer·G WeiM Ladanyi
Oct 18, 2008·Expert Review of Anticancer Therapy·Susan Ann Burchill
Mar 29, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yunlu LiuXianzhe Liu
Feb 28, 2008·The American Journal of Surgical Pathology·Briana C GleasonAntonio R Perez-Atayde
Jun 28, 2002·British Journal of Cancer·C M HattingerD R Betts
Aug 13, 2005·Advances in Anatomic Pathology·Joseph D Khoury
Jan 25, 2012·Nature Reviews. Genetics·David J GordonDavid Pellman
May 25, 2006·The Oncologist·Mark BernsteinHerbert Juergens
Jan 13, 2006·The Oncologist·Michelle Scurr, Ian Judson
Jul 23, 1999·Current Opinion in Oncology·H KovarA Zoubek
May 7, 2002·Journal of Pediatric Hematology/oncology·Hans-Christoph RossbachMaxine J Sutcliffe
Jul 13, 2000·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·M BarnardJ Squire
May 1, 2013·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Miriam LynnMaureen J O'Sullivan
Mar 28, 2018·Oncotarget·Yu TanabeTsuyoshi Saito
Jul 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Geoffrey NealePeter J Houghton
Apr 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kazutaka KikutaTadashi Kondo
Feb 24, 2021·The Journal of Cell Biology·Roshan L ShresthaMunira A Basrai
Apr 27, 2000·Archives of Pathology & Laboratory Medicine·D M HavlikT Bocklage

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