Frequency and phenotype of T helper 17 cells in peripheral blood and synovial fluid of patients with reactive arthritis

The Journal of Rheumatology
Hui ShenJ S Hill Gaston

Abstract

To analyze the frequency and phenotype of peripheral blood mononuclear cells (PBMC) and synovial fluid mononuclear cell (SFMC) T helper (Th)17 cells in reactive arthritis (ReA). T cell surface phenotype and cytokine production were measured following stimulation, using 8-color flow cytometry. The percentages of interleukin 17 (IL-17)-positive CD4+ T cells were increased in SFMC of patients with ReA compared with PBMC. All IL-17+ cells were CD4+CD45RO+; in SFMC most expressed CCR6, but only 50% expressed CCR4. IL-17+ cells sometimes coexpressed IL-22 and/or interferon-γ, but not IL-10. These data support the hypothesis that Th17 cells are involved in ReA pathogenesis.

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Citations

Nov 30, 2013·Arthritis Research & Therapy·Helen BenhamHill Gaston
Nov 15, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Kirsten Braem, Rik J Lories
Nov 22, 2011·Best Practice & Research. Clinical Rheumatology·John D Carter, Robert D Inman
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Feb 8, 2014·Arthritis & Rheumatology·Judith A Smith, Robert A Colbert
Nov 2, 2015·Rheumatology International·Maurizio RossiniDavide Gatti
May 17, 2012·The Journal of Rheumatology·Laurindo Ferreira da RochaMaira Galdino da Rocha Pitta
Jul 7, 2019·Annals of the Rheumatic Diseases·Dennis G McGonagleRobert Moots
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Jun 18, 2021·Frontiers in Medicine·Corinne FisherLucy R Wedderburn

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