PMID: 20634245DOI: 10.3899/jrheum.100146Jul 17, 2010Paper
Frequency and phenotype of T helper 17 cells in peripheral blood and synovial fluid of patients with reactive arthritis
The Journal of Rheumatology
Hui ShenJ S Hill Gaston
Abstract
To analyze the frequency and phenotype of peripheral blood mononuclear cells (PBMC) and synovial fluid mononuclear cell (SFMC) T helper (Th)17 cells in reactive arthritis (ReA). T cell surface phenotype and cytokine production were measured following stimulation, using 8-color flow cytometry. The percentages of interleukin 17 (IL-17)-positive CD4+ T cells were increased in SFMC of patients with ReA compared with PBMC. All IL-17+ cells were CD4+CD45RO+; in SFMC most expressed CCR6, but only 50% expressed CCR4. IL-17+ cells sometimes coexpressed IL-22 and/or interferon-γ, but not IL-10. These data support the hypothesis that Th17 cells are involved in ReA pathogenesis.
References
Oct 1, 1991·Arthritis and Rheumatism·M DougadosG Pasero
Nov 11, 1999·Rheumatology·Z YinJ Sieper
Jan 6, 2001·Arthritis and Rheumatism·A ThielJ Sieper
Jan 27, 2004·The American Journal of Pathology·Guillaume PagePierre Miossec
Apr 19, 2006·European Journal of Immunology·Kerstin WolkRobert Sabat
May 27, 2006·Annals of the Rheumatic Diseases·A W R van KuijkP P Tak
Feb 7, 2007·The Journal of Experimental Medicine·Dragana JankovicAlan Sher
Mar 21, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Daniel WendlingGilles Dumoulin
Aug 24, 2007·Rheumatology·J S H Gaston
Mar 4, 2008·Arthritis and Rheumatism·Kiran NistalaLucy R Wedderburn
Jun 20, 2008·Nature·Estelle BettelliVijay K Kuchroo
Aug 1, 2008·Arthritis and Rheumatism·Camilla JandusPedro Romero
Feb 7, 2009·Annals of the Rheumatic Diseases·Lode MelisDirk Elewaut
May 30, 2009·Arthritis and Rheumatism·Hui ShenJ S Hill Gaston
❮ Previous
Next ❯
Citations
Nov 30, 2013·Arthritis Research & Therapy·Helen BenhamHill Gaston
Nov 15, 2011·Joint, Bone, Spine : Revue Du Rhumatisme·Kirsten Braem, Rik J Lories
Nov 22, 2011·Best Practice & Research. Clinical Rheumatology·John D Carter, Robert D Inman
Apr 13, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Samia J Khoury
Apr 12, 2011·Arthritis and Rheumatism·Elena ZinovievaMaxime Breban
Jan 29, 2014·Arthritis & Rheumatology·Bina MenonBruce W Kirkham
Aug 13, 2014·Clinical and Experimental Immunology·Chunling WuJ S Hill Gaston
Feb 8, 2014·Arthritis & Rheumatology·Judith A Smith, Robert A Colbert
Nov 2, 2015·Rheumatology International·Maurizio RossiniDavide Gatti
Jan 1, 2015·Arthritis Research & Therapy·Mengguo LiuMing Li
Oct 11, 2015·Annals of the Rheumatic Diseases·Matteo VecellioB Paul Wordsworth
May 17, 2012·The Journal of Rheumatology·Laurindo Ferreira da RochaMaira Galdino da Rocha Pitta
Jul 7, 2019·Annals of the Rheumatic Diseases·Dennis G McGonagleRobert Moots
Jun 21, 2018·Frontiers in Immunology·Annika Reinhardt, Immo Prinz
Sep 10, 2020·International Journal of Molecular Sciences·Hiroyuki Tsukazaki, Takashi Kaito
Jul 15, 2018·Nature Reviews. Rheumatology·Leonie S TaamsBruce W Kirkham
Jun 18, 2021·Frontiers in Medicine·Corinne FisherLucy R Wedderburn
❮ Previous
Next ❯
Related Concepts
Related Feeds
Related Papers
Arthritis and Rheumatism
Tri M TranJ D Taurog
Nature Genetics
Wellcome Trust Case Control ConsortiumMathew Brown
Arthritis and Rheumatism
Monica L DeLayRobert A Colbert
Nature Reviews. Immunology
Derrich J ToddLaurie H Glimcher