Abstract
The underlying mechanisms of aggressive pituitary neuroendocrine tumors (pitNETs) are still unclear. The p16 protein, encoded by the CDKN2A tumor suppressor gene on chromosome 9p21, is commonly reported to be lost in numerous types of cancer. For this reason, this study examined to examine the status of homozygous deletion of CDKN2A in high-risk pitNETs. Thirty-eight high-risk pitNETs (30 male, 8 female) were analyzed for CDKN2A deletion by fluorescent in situ hybridization (FISH). Demographic characteristics such as sex, patient age at operation, and sellar magnetic resonance imaging findings including tumor size and invasion status were recorded. The frequency of CDKN2A homozygous deletion by FISH was 3/38 (7.89%) in the high-risk pitNET group. All of these three cases with CDKN2A homozygous deletion were invasive densely granulated lactotroph tumors (p = 0.000). CDKN2A deletion was not correlated with patient age, sex, cavernous sinus invasion (CSI), and tumor size (p > 0.05). The Ki-67 proliferation index was significantly correlated with CDKN2A homozygous deletion (p = 0.003). The mean Ki-67 proliferation index was 10.7% in pitNETs with CDKN2A homozygous deletion and the Ki-67 proliferation index in the whole study group w...Continue Reading
References
Nov 30, 1985·British Medical Journal·M F ScanlonR Hall
Aug 4, 1983·The New England Journal of Medicine·O SerriM Somma
Sep 1, 1994·Neuroendocrinology·L CaccavelliA Enjalbert
Dec 16, 1993·Nature·M SerranoD Beach
Aug 1, 1997·Molecular Carcinogenesis·M WoloschakK D Post
Sep 28, 1999·Oncogene·M F Roussel
Mar 29, 2001·The Journal of Pathology·N SeemannW Paulus
Sep 26, 2001·BMC Cancer·L MastronardiF Puzzilli
Apr 7, 2005·Acta neurochirurgica·S PekerM N Pamir
May 17, 2005·Journal of Neuropathology and Experimental Neurology·Akiyoshi OginoTakao Fukushima
Apr 11, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Geoffrey I Shapiro
Jun 22, 2006·The Journal of Clinical Endocrinology and Metabolism·A F DalyA Beckers
Feb 24, 2010·Nature Reviews. Molecular Cell Biology·Simona NegriniThanos D Halazonetis
Mar 26, 2011·Expert Opinion on Pharmacotherapy·Annamaria ColaoGaetano Lombardi
Sep 7, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhi-Zhou ShiMing-Rong Wang
Oct 1, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kit W TamAdi Gazdar
Apr 8, 2014·Genes, Chromosomes & Cancer·Vera RiehmerUNKNOWN German Glioma Network
Oct 27, 2015·CNS Oncology·Debebe TheodrosChetan Bettegowda
Nov 16, 2016·Oncotarget·Congxin DaiRenzhi Wang
Aug 3, 2017·Endocrine Pathology·Ozgur Mete, M Beatriz Lopes
Sep 7, 2017·Journal of Neurological Surgery. Part B, Skull Base·Michael A MooneyAndrew S Little
Apr 25, 2018·Brain Tumor Pathology·Naoko Inoshita, Hiroshi Nishioka
Jun 25, 2018·Pituitary·Winnie LiuMaria Fleseriu
Jul 11, 2018·Endocrine-related Cancer·Dorota Dworakowska, Ashley B Grossman
Oct 12, 2018·Endocrine-related Cancer·Dorota Dworakowska, Ashley B Grossman
Jan 6, 2019·Endocrine Pathology·Rovshan HasanovSevim Güllü