PMID: 9186829May 1, 1997Paper

Frequency and significance of antibodies to P450IID6 protein in Japanese patients with chronic hepatitis C

Journal of Hepatology
M NishiokaM P Manns

Abstract

The aims of the current study were to assess the frequency and the significance of antibodies to cytochrome P450IID6 protein (anti-P450IID6) in various diseases among Japanese patients. Sera from 541 patients were tested by indirect immunofluorescence, and the specificity of anti-P450IID6 was ascertained by either enzyme immunoassay (ELISA) or Western blot using recombinant antigen or rat liver microsomes. Anti-P450IID6 was found in only 6 of 235 patients (2.6%) with chronic active hepatitis (CAH) positive for hepatitis C virus (HCV) antibody and quantitative HCV-RNA with genotypes II and IV. The predominant epitopes on immunoblots were 66 and 50KD, a 10KD band being the newly underfined microsomal antigen. Even in the patients negative for autoantibodies to nuclear antigens (ANA) by routine indirect immunofluorescence test, various ANA were detected by the newly developed recombinant ELISA. These patients were younger, with lower gamma-globulin and IgG levels than patients with autoimmune hepatitis. Three of five patients with anti-P450IID6 responded well to interferon therapy and one received prednisone when interferon was ineffective. Interestingly, only this patient was diagnosed as definite autoimmune hepatitis according t...Continue Reading

References

Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F LunelJ M Huraux
Oct 1, 1991·The Journal of Clinical Investigation·M P MannsE F Johnson
Sep 1, 1991·Journal of Clinical Immunology·N ZurgilY Shoenfeld
Dec 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T SekiM Ota
Jan 1, 1990·Springer Seminars in Immunopathology·M P Manns, K H Meyer zum Büschenfelde
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S L DeutscherJ D Keene
Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C HombergP Grippon
Mar 1, 1986·The Journal of Pediatrics·G MaggioreD Alagille
Sep 14, 1968·Lancet·J De GrooteE Uehlinger
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Feb 1, 1995·Gastroenterology·J C Duclos-ValléeF Alvarez
Jul 1, 1993·Journal of Hepatology·N AbuafJ C Homberg
Mar 1, 1993·Journal of Hepatology·D PateronM Beaugrand
Apr 1, 1993·Digestive Diseases and Sciences·M W FriedA M Di Bisceglie
Oct 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P J Johnson, I G McFarlane

❮ Previous
Next ❯

Citations

Dec 26, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·Masahiro KimuraNobuyuki Amino
Oct 22, 2003·Journal of Hepatology·Georgios N DalekosMichael P Manns
Jul 30, 2002·European Journal of Internal Medicine·G N. DalekosN Gatselis
Oct 5, 2002·Clinics in Liver Disease·Kirsten Muri Boberg
Jan 10, 2002·European Journal of Gastroenterology & Hepatology·Georgios N DalekosMichael P Manns
Mar 21, 1998·Journal of Gastroenterology and Hepatology·M NishiokaM P Manns
Sep 19, 2012·Clinical & Developmental Immunology·Takashi Himoto, Tsutomu Masaki
Apr 25, 2000·Biochemical and Biophysical Research Communications·M HijikataS Mishiro
Sep 10, 2013·Alimentary Pharmacology & Therapeutics·K ZachouL Muratori
Jun 13, 2006·Cellular Immunology·Xiao-Song HeM Eric Gershwin
Dec 18, 2004·Human Immunology·Yasunobu FukudaTomohiro Kato
May 10, 2017·Expert Review of Clinical Immunology·Paolo MuratoriLuigi Muratori
May 4, 2013·Expert Review of Gastroenterology & Hepatology·Albert J Czaja
Aug 1, 2013·Auto- Immunity Highlights·Takashi Himoto, Mikio Nishioka
Apr 11, 2018·Frontiers in Immunology·Marcial SebodeChristoph Schramm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.