PMID: 11340873May 9, 2001Paper

Frequency dependence of dynamic curvature effects on flow through coronary arteries

Journal of Biomechanical Engineering
J A MooreA Santamarina

Abstract

The flow through a curved tube model of a coronary artery was investigated computationally to determine the importance of time-varying curvature on flow patterns that have been associated with the development of atherosclerosis. The entry to the tube was fixed while the radius of curvature varied sinusoidally in time at a frequency of 1 or 5 Hz. Angiographic data from other studies suggest that the radius of curvature waveform contains significant spectral content up to 6 Hz. The overall flow patterns were similar to those observed in stationary curved tubes; velocity profile skewed toward the outer wall, secondary flow patterns, etc. The effects of time-varying curvature on the changes in wall shear rate were expressed by normalizing the wall shear rate amplitude with the shear rate calculated at the static mean radius of curvature. It was found that the wall shear rate varied as much as 94 percent of the mean wall shear rate at the mid wall of curvature for a mean curvature ratio of 0.08 and a 50 percent change in radius of curvature. The effects of 5 Hz deformation were not well predicted by a quasi-static approach. The maximum values of the normalized inner wall shear rate amplitude were found to scale well with a dimension...Continue Reading

Citations

Feb 26, 2008·Biomechanics and Modeling in Mechanobiology·J Scott VanEppsDavid A Vorp
Jan 29, 2005·Annals of Biomedical Engineering·S D RamaswamyK B Chandran
Oct 20, 2006·Annals of Biomedical Engineering·Maheshwaran K KolandavelPeter G Walker
Aug 17, 2001·Journal of Biomechanics·E S Weydahl, J E Moore
Mar 15, 2006·Journal of Biomechanical Engineering·S D RamaswamyK B Chandran
Jul 1, 2012·Journal of Biomechanical Engineering·N K C Selvarasu, Danesh K Tafti
Feb 22, 2016·Biomedical Engineering Online·Jiang XuYaling Liu
Nov 3, 2010·Progress in Biophysics and Molecular Biology·Sarah L WatersFrans N van de Vosse
Oct 12, 2010·Atherosclerosis·Ernst WellnhoferLeonid Goubergrits
Sep 25, 2004·Journal of Biomechanics·Martin ProsiMorton H Friedman
Dec 23, 2008·The Annals of Thoracic Surgery·Lindsay C H John
Jun 3, 2014·Journal of Biomechanical Engineering·N K C Selvarasu, Danesh K Tafti

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