PMID: 22587133May 17, 2012Paper

Frequency-dependent signal transfer at the interface between electrogenic cells and nanocavity electrodes

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Manuel SchottdorfBernhard Wolfrum

Abstract

We present a model to describe the response of chip-based nanocavity sensors during extracellular recording of action potentials. These sensors feature microelectrodes which are embedded in liquid-filled cavities. They can be used for the highly localized detection of electrical signals on a chip. We calculate the sensor's impedance and simulate the propagation of action potentials. Subsequently we apply our findings to analyze cell-chip coupling properties. The results are compared to experimental data obtained from cardiomyocyte-like cells. We show that both the impedance and the modeled action potentials fit the experimental data well. Furthermore, we find evidence for a large seal resistance of cardiomyocytes on nanocavity sensors compared to conventional planar recording systems.

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Citations

Oct 4, 2015·Journal of Neuroscience Methods·Robert SamhaberFred Wolf
Sep 1, 2016·Scientific Reports·Jules J VanDersarl, Philippe Renaud
Dec 28, 2016·Biosensors·Dmitry KireevAndreas Offenhäusser
May 6, 2015·Nanoscale·Anna CzeschikBernhard Wolfrum
Apr 4, 2017·Advanced Healthcare Materials·Dmitry KireevAndreas Offenhäusser
Nov 15, 2012·Nanotechnology·Manuel WescheBernhard Wolfrum
Aug 21, 2013·Advanced Healthcare Materials·Vanessa MaybeckAndreas Offenhäusser
Apr 19, 2012·Analytical Chemistry·Alexey YakushenkoBernhard Wolfrum
May 16, 2018·ACS Applied Materials & Interfaces·Aleksandr MarkovRoger Wördenweber

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