PMID: 2092297Dec 1, 1990Paper

Frequency distribution of lymphatic filariasis microfilariae in human populations: population processes and statistical estimation

Parasitology
B T GrenfellD A Bundy

Abstract

This paper uses simple mathematical models and statistical estimation techniques to analyse the frequency distribution of microfilariae (mf) in blood samples from human populations which are endemic for lymphatic filariasis. The theoretical analysis examines the relationship between microfilarial burdens and the prevalence of adult (macrofilarial) worms in the human host population. The main finding is that a large proportion of observed mf-negatives may be 'true' zeros, arising from the absence of macrofilarial infections or unmated adult worms, rather than being attributable to the blood sampling process. The corresponding mf distribution should then follow a Poisson mixture, arising from the sampling of mf positives, with an additional proportion of 'true' mf-zeros. This hypothesis is supported by analysis of observed Wuchereria bancrofti mf distributions from Southern India, Japan and Fiji, in which zero-truncated Poisson mixtures fit mf-positive counts more effectively than distributions including the observed zeros. The fits of two Poisson mixtures, the negative binomial and the Sichel distribution, are compared. The Sichel provides a slightly better empirical description of the mf density distribution; reasons for this i...Continue Reading

References

Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·C E Herron, I D Forsythe
Jan 1, 1985·Advances in Parasitology·R M Anderson, R M May
Jan 1, 1971·Transactions of the Royal Society of Tropical Medicine and Hygiene·D A DenhamF Guy
Sep 1, 1965·Transactions of the Royal Society of Tropical Medicine and Hygiene·G Macdonald

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Citations

Jan 1, 1997·Parasitology Today·K Wilson, B T Grenfell
Jul 7, 1999·Veterinary Parasitology·A FentonN P French
Aug 1, 1996·Epidemiology and Infection·A SrividyaD A Bundy
Jun 20, 1998·Proceedings. Biological Sciences·E Michael, D A Bundy
Jan 1, 1992·Parasitology·B T Grenfell, E Michael
Nov 1, 1991·Parasitology Today·B T GrenfellD A Denham
Jun 15, 2007·Veterinary Parasitology·Richard Wall
Sep 5, 2012·Tropical Medicine & International Health : TM & IH·Neal Alexander
Mar 28, 2006·Trends in Parasitology·Edwin MichaelJames W Kazura
Dec 23, 1999·Medical and Veterinary Entomology·A FentonN P French

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