PMID: 15385838Sep 24, 2004Paper

Frequency distribution of thiopurine S-methyltransferase alleles in a polish population

Therapeutic Drug Monitoring
Mateusz KurzawskiMarek Drozdzik

Abstract

Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine, and azathioprine. TPMT activity exhibits an interindividual variability mainly a result of genetic polymorphism. Patients with intermediate or deficient TPMT activity are at risk for toxicity after receiving standard doses of thiopurine drugs. It has previously been reported that 3 variant alleles:TPMT*2, *3A, and *3C are responsible for over 95% cases of lower enzyme activity. The purpose of this study was to determine the frequency of TPMT variant alleles in a Polish population. DNA samples were obtained from 358 unrelated healthy Polish subjects of white origin, and TPMT genetic polymorphism was determined using PCR-RFLP and allele-specific PCR methods. The results showed that allelic frequencies were 0.4% for TPMT*2, 2.7% for TPMT*3A, and 0.1% for TPMT*3C, respectively. A TPMT*3B allele was not found in the studied population. The general pattern of TPMT allele disposition in the Polish population is similar to those determined for other white populations, but the frequency of total variant alleles is lower than in other European populations studied to date.

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Citations

May 29, 2008·European Journal of Clinical Pharmacology·Srikumar SahasranamanSandip Roy
Dec 3, 2008·European Journal of Clinical Pharmacology·Edna EfratiEli Sprecher
Feb 21, 2009·European Journal of Clinical Pharmacology·Mateusz KurzawskiMarek Drozdzik
Jun 4, 2010·European Journal of Clinical Pharmacology·Nancy HakoozWilliam Newman
May 26, 2006·European Journal of Human Genetics : EJHG·Tatyana V NasedkinaAlexander S Zasedatelev
Dec 21, 2012·Genetic Testing and Molecular Biomarkers·Marzena Skrzypczak-ZielinskaRyszard Slomski
Apr 12, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Mateusz KurzawskiMarek Droździk
Aug 22, 2006·Alimentary Pharmacology & Therapeutics·L J J DerijksD W Hommes
Jun 23, 2006·Journal of Clinical Pharmacy and Therapeutics·R RossinoM Congia
Nov 27, 2008·Pediatric Blood & Cancer·Elena V SamochatovaRaul C Ribeiro
Jan 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Laurence J EganDaniel W Hommes
Jan 26, 2012·Orvosi hetilap·Csilla SipekyBéla Melegh
Apr 22, 2010·Nucleosides, Nucleotides & Nucleic Acids·Ali BahariBehzad Narouie
Mar 8, 2018·Clinical Pharmacokinetics·Luc J J DerijksAdriaan A van Bodegraven
Sep 1, 2017·European Journal of Gastroenterology & Hepatology·Constantina CoucoutsiElias A Kouroumalis
Sep 15, 2018·Oncology Letters·Joanna SobiakJacek Wachowiak
Feb 1, 2006·Personalized Medicine·Monica ArenasJeremy Sanderson

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