Frequency of -163 C>A and 63 C>G single nucleotide polymorphism of cytochrome P450 1A2 in two African populations

Clinical Chemistry and Laboratory Medicine : CCLM
Collet DandaraJulia A Hasler

Abstract

Cytochrome P450 1A2 (CYP1A2) is an important member of the cytochrome P450 superfamily of enzymes because of its involvement in the metabolism of some carcinogens and therapeutically important drugs. As a result, factors affecting the activity of the enzyme are the focus of considerable research effort as they may have important pharmacological or toxicological implications. CYP1A2 has been shown to exhibit a genetic polymorphism with most of the data, however, coming from studies in Caucasian and Oriental populations. In this study therefore, we investigated the frequencies of two point mutations, -163C>A and 63C>G, in two Bantu African populations. A total of 214 healthy subjects were recruited from Zimbabwe (n=143) and Tanzania (n=71). The two single nucleotide polymorphisms were detected using polymerase chain reaction-restriction fragment length polymorphism analysis. The frequency of -163A was 57% (95% confidence interval (CI), 54%, 60%) and 49% (95% CI, 45%, 53%) among Zimbabweans and Tanzanians, respectively, but the difference between the two populations was not statistically significant (p=0.123). The base change 63 C>G was not found in any of the subjects from the two populations. We report here a high frequency of -...Continue Reading

References

Mar 1, 1985·Clinical Pharmacology and Therapeutics·B J CusackR E Vestal
Jan 1, 1995·Clinical Pharmacology and Therapeutics·C M MasimirembwaW Kalow
Jul 19, 2001·Cancer Chemotherapy and Pharmacology·G G SofoworaG R Wilkinson
Jan 23, 2002·Neuropsychobiology·Reiji YoshimuraMasakazu Matsushita
Apr 17, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·V M BreinholtT Friedberg
May 9, 2002·Drug Metabolism Reviews·Slobodan Rendic
Nov 26, 2002·British Journal of Clinical Pharmacology·Anna NordmarkAnders Rane
Nov 26, 2002·British Journal of Clinical Pharmacology·Xing-Mei HanHong-Hao Zhou
Mar 13, 2003·British Journal of Clinical Pharmacology·Samar I HamdyMichinao Mizugaki
Oct 18, 2003·The Journal of Pharmacology and Experimental Therapeutics·Norie MurayamaJun-ichi Sawada

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Citations

Nov 25, 2005·European Journal of Clinical Pharmacology·Carsten SkarkeJörn Lötsch
Mar 5, 2014·Expert Opinion on Drug Metabolism & Toxicology·Collet DandaraCollen Masimirembwa
Apr 18, 2013·Drug Metabolism Reviews·Marco AlessandriniMichael Sean Pepper
May 7, 2013·Expert Opinion on Drug Metabolism & Toxicology·Vidya PereraAndrew J McLachlan
Aug 26, 2006·Cell Biochemistry and Function·Junko FujiharaHaruo Takeshita

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