Frequency of adult type-associated lactase persistence LCT-13910C/T genotypes in the Czech/Slav and Czech Roma/Gypsy populations

Genetics and Molecular Biology
Jaroslav A HubácekValérie Tóthová

Abstract

Lactase non-persistence (leading to primary lactose intolerance) is a genetically dependent inability to digest lactose in adulthood. As part of the human adaptation to dairying, the human lactase LCT-13910C/T mutation (which propagates adult expression of lactase) developed, spread and participated in the adaptation to dairying. This variant is associated with lactase activity persistence, and its carriers are able to digest lactose. We compared the frequencies of lactase 13910C/T (rs4988235) genotypes in Czechs/Slavs (N = 288) and Czech Gypsies/Roma (N = 300), two ethnically different groups where this polymorphism has not yet been analysed. Allelic frequencies significantly differed between the populations (p < 0.0001). In Czechs/Slavs, the lactase persistence T allele was present in 76% of the individuals, which is in agreement with frequencies among geographically neighbouring populations. In the Czech Gypsy/Roma population, only 27% of the adults were carriers of at least one lactase persistence allele, similar to the Indian population. In agreement with this result, dairy product consumption was reported by 70.5% of Czechs/Slavs and 39.0% of the Czech Gypsy/Roma population. Both in the Czech Gypsy/Roma and in the Czech/S...Continue Reading

References

Jun 1, 1995·Journal of Public Health Medicine·A O HughesN Tibbs
May 10, 2005·International Journal of Cancer. Journal International Du Cancer·Mikko KuokkanenIrma Järvelä
Apr 9, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Carmen G TagRalf Weiskirchen
Aug 29, 2009·PLoS Computational Biology·Yuval ItanMark G Thomas
Mar 3, 2011·American Journal of Physical Anthropology·Dóra NagyIstván Raskó
Jul 25, 2012·Clinical and Experimental Gastroenterology·Rejane MattarFlair José Carrilho
Dec 18, 2013·IUBMB Life·Pascale GerbaultMark G Thomas
Jan 1, 2013·Human Heredity·Pascale Gerbault
Nov 11, 2014·Annual Review of Ecology, Evolution, and Systematics·Joseph Lachance, Sarah A Tishkoff

❮ Previous
Next ❯

Citations

Apr 14, 2018·Journal of Pediatric Gastroenterology and Nutrition·Malla I NeuvonenMikko P Pakarinen
Jan 21, 2019·Central European Journal of Public Health·Jaroslav A HubáčekValérie Tóthová
Jun 25, 2020·Molecular Genetics & Genomic Medicine·Jaroslav A HubáčekValérie Tóthová
Jul 2, 2020·Drug Metabolism and Personalized Therapy·Lucie DlouháValérie Tóthová
Oct 12, 2021·Experimental and Therapeutic Medicine·Corina PienarEdward Șeclăman

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.