Frequency of aminoglycoside 6'-N-acetyltransferase among Serratia species during increased use of amikacin in the hospital.

Antimicrobial Agents and Chemotherapy
T A LarsonD N Gerding

Abstract

The incidence of tobramycin-resistant, gentamicin-susceptible Serratia species at the Minneapolis Veterans Administration Medical Center decreased from an average 42.1 to 2.5% (P less than 0.001) during a 4.5-year period despite the predominant use of amikacin. These organisms were shown to express a 6'-N-acetyltransferase-modifying enzyme (EC 2.3.1.82). Resistance was not shown to be plasmid mediated.

References

Feb 1, 1985·The Journal of Infectious Diseases·J F LevineJ J Rahal
May 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·R RadloffJ Vinograd
Apr 1, 1982·Antimicrobial Agents and Chemotherapy·J F JohnP A Kresel
Jul 1, 1981·The Journal of Antimicrobial Chemotherapy·K E PriceS A Karpow

❮ Previous
Next ❯

Citations

Apr 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R VanhoofE Roebben
Aug 1, 1996·International Journal of Antimicrobial Agents·D C GarcíaD O Sordelli
Feb 1, 1994·Epidemiology and Infection·R Coria-Jiménez, C Ortiz-Torres
Jul 1, 1991·Antimicrobial Agents and Chemotherapy·D N GerdingL R Peterson
Nov 1, 1992·Antimicrobial Agents and Chemotherapy·A Fernandez-RodriguezF Baquero
Aug 1, 1992·Antimicrobial Agents and Chemotherapy·I R FriedlandK P Klugman
Apr 1, 1990·AORN Journal·D G McQuarrieM M Olson
Dec 1, 1991·Journal of Chemotherapy·M A ToscanoG Nicoletti

❮ Previous
Next ❯

Related Concepts

Related Feeds

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.