Frequency of Aminoglycoside-Modifying Enzymes and ArmA Among Different Sequence Groups of Acinetobacter baumannii in Iran

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Alka HasaniHamid Reza Goli

Abstract

We evaluated aminoglycoside resistance in 87 Acinetobacter baumannii strains isolated from four hospitals located in the North West region of Iran and typed them in sequence groups (SGs) using trilocus sequence-based scheme to compare their clonal relationships with international clones. Resistance toward aminoglycosides was assayed by minimum inhibitory concentration (MIC) and presence of aminoglycoside-modifying enzymes (AMEs), and ArmA-encoding genes were evaluated in different SGs. The majority of isolates belonged to SG1 (39%), SG2 (33.3%), and SG3 (12.6%), whereas the remaining ones were assigned to six novel variants of SGs. MIC determination revealed netilmicin as the most and kanamycin as the least active aminoglycosides against all groups. Among the varied SGs, isolates of SG2 showed more susceptibility toward all tested aminoglycosides. APH(3'')-VIa-encoding gene was predominant in SG1 (47%), SG2 (62%), and SG6-9 (100%). However, AAC(3')-Ia (100%) and ANT(2')-Ia (90.9%) were the dominant AMEs in SG3. There was significant association between harboring of aminoglycoside resistance genes and specific aminoglycosides: gene encoded by APH(3')-VIa was allied to resistance against amikacin and kanamycin, whereas ANT(2')-Ia...Continue Reading

References

Jun 1, 1995·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M ValtonenJ Lähdevirta
Apr 1, 1996·Clinical Microbiology Reviews·E Bergogne-Bérézin, K J Towner
Oct 6, 1999·Current Opinion in Microbiology·G D Wright
Mar 7, 2006·Journal of Clinical Microbiology·Bernard La ScolaDidier Raoult
Mar 3, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G Da SilvaA Duarte
Apr 21, 2007·Cellular and Molecular Life Sciences : CMLS·T Hermann
Jun 8, 2007·Emerging Infectious Diseases·Kunikazu YamaneYoshichika Arakawa
Jul 6, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J F TurtonT L Pitt
Sep 6, 2007·Antimicrobial Agents and Chemotherapy·Yohei DoiDavid L Paterson
Dec 21, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K J TownerUNKNOWN ARPAC Steering Group
Jul 16, 2008·Clinical Microbiology Reviews·Anton Y PelegDavid L Paterson
Dec 10, 2009·The Journal of Antimicrobial Chemotherapy·Paul G HigginsHarald Seifert
Oct 12, 2010·Journal of Global Infectious Diseases·Vikas ManchandaNp Singh
Apr 24, 2012·International Journal of Antimicrobial Agents·Amir PeymaniHarald Seifert
Jun 26, 2012·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Tanya StratevaIvan Mitov
Apr 13, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mohammad AghazadehZoya Hojabri
Jun 19, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abbas BahadorReza Raoofian
Aug 14, 2013·Antimicrobial Agents and Chemotherapy·Dae Hun KimKwan Soo Ko
Oct 15, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Natacha MartinsBeatriz Meurer Moreira
Feb 25, 2014·The Journal of Antimicrobial Chemotherapy·Zoya HojabriCaterina Mammina
Jul 12, 2014·Diagnostic Microbiology and Infectious Disease·Xuejun GuoJonathan R Iredell

❮ Previous
Next ❯

Citations

Dec 14, 2019·Acta Microbiologica Et Immunologica Hungarica·Farkhondeh Saleh ShooshtariHamed Goodarzi
Aug 29, 2018·Antimicrobial Agents and Chemotherapy·Anelise S BallabenYohei Doi
Mar 30, 2017·Frontiers in Cellular and Infection Microbiology·Chang-Ro LeeSang Hee Lee
May 15, 2020·Clinical Microbiology Reviews·David M P De OliveiraMark J Walker
Feb 6, 2021·Pathogens·Gustavo Henrique Rodrigues Vale de MacedoLuís Cláudio Nascimento da Silva
Feb 4, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Maryam Asadi JouybariHamid Reza Goli

❮ Previous
Next ❯

Methods Mentioned

BETA
phosphotransferases
PCR
PCRs

Software Mentioned

3LST

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Acinetobacter Infections

Acinetobacter infections have become common in hospitalized patients, especially in the intensive care unit setting and are difficult to treat due to their propensity to develop antimicrobial drug resistance. Discover the latest research on Acinetobacter Infections here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.