Frequency of and Factors Associated With Obstructive Sleep Apnea and Periodic Limb Movements in Stroke and TIA Patients

The Neurologist
Gaurav GadodiaFadi Nahab

Abstract

Obstructive sleep apnea (OSA) and periodic limb movements (PLMs) have been associated with an increased risk of cardiovascular disease. There is limited data on the relationship between OSA and PLMs with atrial fibrillation and resistant hypertension in stroke and transient ischemic attack (TIA) patients. Consecutive stroke and TIA patients referred by a vascular neurologist for diagnostic polysomnography (PSG) from September 1, 2012 to August 31, 2015 were included in a retrospective analysis. Baseline clinical characteristics, PSG results and outcomes were collected to identify the frequency of and factors associated with PLMs (mild 5 to 10/h; severe ≥15/h), PLM arousals (≥5/h) and moderate-severe OSA (apna-hypopnea Index ≥15) including atrial fibrillation and resistant hypertension. Among 103 patients (mean age, 60±15 y; 50% female; 61% nonwhites; 77% ischemic stroke; 23% resistant hypertension) who underwent PSG, 20% had mild PLMs, 28% had severe PLMs, 14% had PLM arousals, and 22% had moderate-severe OSA. Factors associated with moderate-severe OSA included older age (odds ratio, 1.06; 95% confidence interval, 1.02-1.11) and presence of atrial fibrillation (odds ratio, 4.26; 95% confidence interval, 1.17-15.44). Nonwhite r...Continue Reading

References

Mar 1, 1996·Stroke; a Journal of Cerebral Circulation·M E DykenM B Zimmerman
Jun 1, 1997·Psychiatry and Clinical Neurosciences·J Espinar-SierraM Luque-Otero
Nov 12, 2005·The New England Journal of Medicine·H Klar YaggiVahid Mohsenin
Aug 5, 2006·Stroke; a Journal of Cerebral Circulation·Roberto MunozGermán De La Torre
Apr 20, 2007·Parkinsonism & Related Disorders·GianPietro SechiKai Stephan Paulus
Jul 20, 2007·The New England Journal of Medicine·Hreinn StefanssonKari Stefansson
Mar 31, 2012·Expert Review of Cardiovascular Therapy·Aneesa M Das, Meena Khan
Dec 25, 2012·Journal of Neurology·Jessica KepplingerUlf Bodechtel
Apr 16, 2014·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Nathaniel S MarshallRonald R Grunstein
Feb 16, 2015·The Lancet. Respiratory Medicine·R HeinzerJ Haba-Rubio
Sep 29, 2015·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Panagis DrakatosAdrian Williams
Dec 26, 2015·Annals of Neurology·José Haba-RubioRaphaël Heinzer
Aug 30, 2016·The New England Journal of Medicine·R Doug McEvoyUNKNOWN SAVE Investigators and Coordinators
Aug 30, 2016·The New England Journal of Medicine·Babak Mokhlesi, Najib T Ayas
Nov 9, 2016·Sleep Medicine·Anna M MayUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

© 2022 Meta ULC. All rights reserved