Frequency of Brain Metastases and Multikinase Inhibitor Outcomes in Patients With RET-Rearranged Lung Cancers

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Alexander DrilonOliver Gautschi

Abstract

In ret proto-oncogene (RET)-rearranged lung cancers, data on the frequency of brain metastases and, in particular, the outcomes of multikinase inhibitor therapy in patients with intracranial disease are not well characterized. A global, multi-institutional registry (cohort A, n = 114) and a bi-institutional data set (cohort B, n = 71) of RET-rearranged lung cancer patients were analyzed. Patients were eligible if they had stage IV lung cancers harboring a RET rearrangement by local testing. The incidence of brain metastases and outcomes with multikinase inhibitor therapy were determined. The frequency of brain metastases at the time of diagnosis of stage IV disease was 25% (95% confidence interval [CI]: 18%-32%) in all patients from both cohorts. The lifetime prevalence of brain metastasis in stage IV disease was 46% (95% CI: 34%-58%) in patients for whom longitudinal data was available. The cumulative incidence of brain metastases was significantly different (p = 0.0039) between RET-, ROS1-, and ALK receptor tyrosine kinase (ALK)-rearranged lung cancers, with RET intermediate between the other two groups. Although intracranial response data was not available in cohort A, the median progression-free survival of multikinase inhi...Continue Reading

Citations

Aug 2, 2019·Expert Review of Anticancer Therapy·Johan Filip VansteenkistePierre Van Mol
Aug 31, 2019·Cancer·Jessica J Lin, Justin F Gainor
Nov 12, 2019·Carcinogenesis·Takashi KohnoTakashi Nakaoku
Aug 8, 2020·Nature Reviews. Clinical Oncology·Alexander DrilonMonika A Davare
Aug 28, 2020·The New England Journal of Medicine·Alexander DrilonVivek Subbiah
Feb 26, 2020·International Journal of Molecular Sciences·Aaron C TanMustafa Khasraw
Aug 22, 2020·World Journal of Clinical Oncology·Dexter P MendozaSubba R Digumarthy
Jan 23, 2019·Frontiers in Physiology·Lois M Mulligan
Jul 16, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Carmen BelliGiuseppe Curigliano
Nov 17, 2020·Expert Review of Anticancer Therapy·Ariane Steindl, Anna S Berghoff
Feb 5, 2021·Frontiers in Oncology·Yalin KangXianglin Yuan
Oct 29, 2020·Journal of Hematology & Oncology·Liling HuangYuankai Shi
Sep 27, 2020·Cancer Treatment Reviews·Jordi RemonBenjamin Besse
Mar 17, 2021·Critical Reviews in Oncology/hematology·Alessandro De TomaMarina Chiara Garassino
Mar 28, 2021·Journal of Hematology & Oncology·Leylah M DrusboskyChukwuemeka V Ikpeazu
Mar 29, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Bing Xia, Sai-Hong Ignatius Ou
Mar 31, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Misako Nagasaka, Sai-Hong Ignatius Ou
May 3, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Georg Pall, Oliver Gautschi
May 30, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Viola W ZhuMisako Nagasaka
Jun 23, 2021·Journal of Neuro-oncology·Gautam U MehtaHarpreet Singh
Jun 25, 2021·Current Treatment Options in Oncology·Fangdi Sun, Caroline E McCoach
Jun 25, 2021·Cancer Treatment and Research Communications·Sheon BabyTawee Tanvetyanon
Jul 10, 2021·Journal of Hematology & Oncology·Umair MajeedYanyan Lou
Jun 6, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vivek SubbiahAlexander Drilon
Aug 16, 2021·Trends in Cancer·Kyaw Z TheinVivek Subbiah
Aug 21, 2021·Bioorganic & Medicinal Chemistry·Thais Cristina Mendonça Nogueira, Marcus Vinicius Nora de Souza
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yaogeng WangAlfred H Schinkel
Jan 6, 2022·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David Chun Cheong TsuiChad G Rusthoven

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved