Frequency of Clinical Monitoring of Serum Concentrations of Digoxin, Potassium, and Creatinine, and Recording of Electrocardiograms in Digoxin-Treated Patients: A Japanese Claims Database Analysis

Biological & Pharmaceutical Bulletin
Nobuhiro OobaNoriyasu Fukuoka

Abstract

Guidelines for cardiovascular drug therapy recommend monitoring serum digoxin concentration (SDC) in patients receiving digoxin treatment, especially those with renal dysfunction and hypokalemia. However, only a few studies have reported the prevalence of SDC monitoring and laboratory testing in clinical practice. Therefore, the aim of this study was to describe the frequency of SDC monitoring and laboratory testing in digoxin users and to assess the association between SDC monitoring and patient characteristics. We used the Japanese insurance claims data covering approximately 1.7 million patients aged 20-74 years between January 1, 2005 and March 31, 2014. All patients who had at least one prescription for digoxin were included. The frequency of SDC and laboratory tests was calculated and the association between patient characteristics and SDC monitoring was assessed using logistic regression analysis. A total of 98867 prescriptions of digoxin were issued to 3458 patients between 2005 and 2014. The annual mean frequencies of monitoring SDC, serum potassium level and serum creatinine level and of recording electrocardiograms was 16.8, 34.8, 38.7, and 24.1%, respectively. Atrial fibrillation, chronic heart failure, renal diseas...Continue Reading

References

Feb 18, 2003·JAMA : the Journal of the American Medical Association·Saif S RathoreHarlan M Krumholz
Jan 22, 2005·Journal of Clinical Pharmacy and Therapeutics·M TakadaM Shibakawa
Jan 21, 2006·Journal of General Internal Medicine·Marsha A RaebelRichard Platt
Feb 3, 2007·Journal of Managed Care Pharmacy : JMCP·Marsha A RaebelRichard Platt
Aug 20, 2011·The Annals of Pharmacotherapy·Jennifer TjiaTerry S Field
Jan 18, 2013·European Heart Journal·Dirk J van VeldhuisenMihai Gheorghiade
Jun 12, 2013·Journal of the American College of Cardiology·Clyde W YancyUNKNOWN American Heart Association Task Force on Practice Guidelines
Dec 5, 2013·Circulation. Heart Failure·Isaac SeeDaniel S Budnitz
Oct 21, 2016·Circulation. Cardiovascular Quality and Outcomes·Matthew L MaciejewskiBradley G Hammill
Nov 29, 2016·JAMA : the Journal of the American Medical Association·Nadine ShehabDaniel S Budnitz
Mar 18, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Kazutaka AonumaUNKNOWN Japanese Circulation Society and the Japanese Society of Therapeutic Drug Monitoring Joint Working Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.