Frequency of familial hypercholesterolemia in patients with early-onset coronary artery disease admitted to a coronary care unit

Journal of Clinical Lipidology
Jing PangGerald F Watts

Abstract

Familial hypercholesterolemia (FH) is the most common dominantly inherited cause of premature coronary artery disease (CAD). However, the diagnosis of FH in patients who have premature CAD in hospital settings is under-recognized, this also represents a missed opportunity for screening their close family members and implementing primary prevention. To investigate the point prevalence of FH in a coronary care unit (CCU) among patients with early-onset CAD. The prevalence of FH, based on modified phenotypic Dutch Lipid Clinic Network Criteria, and the spectrum of associated CAD risk factors, were investigated in a CCU setting. Data were collected on 175 coronary care patients with onset of CAD at age <60 years. The prevalence of probable/definite FH was 14.3% (95% confidence interval, 9.0%-19.5%); 46.3% of the patients gave a family history of premature CAD and 20.6% had an untreated low-density lipoprotein cholesterol >5.0 mmol/L. Diabetes, hypertension, obesity, and smoking were common and equally prevalent in patients with and without FH. FH is relatively frequent among patients with a history of early-onset CAD in the CCU. Every effort should be made to detect FH in these patients and to initiate cascade testing of available ...Continue Reading

References

Jul 1, 1973·The Journal of Clinical Investigation·J L GoldsteinA G Motulsky
Feb 24, 2001·BMJ : British Medical Journal·M F DorschA S Hall
Mar 7, 2001·The American Journal of Cardiology·P N HopkinsS C Hunt
Jan 26, 2002·Human Genetics·S W FouchierJ P Kastelein
Jan 25, 2003·Journal of Internal Medicine·P R W de Sauvage NoltingJ J P Kastelein
Jun 17, 2004·Seminars in Vascular Medicine·David WonderlingMargaret Thorogood
Aug 9, 2007·Heart, Lung & Circulation·Timothy R BatesGerald F Watts
Sep 5, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Loukianos S RallidisDimitrios T Kremastinos
Oct 23, 2008·The American Journal of Cardiology·Fernando CiveiraMiguel Pocovi
Nov 13, 2008·BMJ : British Medical Journal·Jorie VersmissenEric J G Sijbrands
Mar 12, 2009·European Heart Journal·Franz WiesbauerMartin Schillinger
Sep 16, 2011·Atherosclerosis. Supplements·Gerald F WattsUNKNOWN Familial Hypercholesterolaemia Australasia Network Consensus Group (Australian Atherosclerosis Society)
May 29, 2012·Heart, Lung & Circulation·Gerald F WattsUNKNOWN Familial Hypercholesterolaemia Australasia Network
Aug 14, 2012·Atherosclerosis·Amanda J HooperFrank M van Bockxmeer
Aug 16, 2012·The Journal of Clinical Endocrinology and Metabolism·Marianne BennBørge G Nordestgaard
Jan 15, 2014·International Journal of Cardiology·Gerald F WattsJohn J P Kastelein
Dec 3, 2014·The Canadian Journal of Cardiology·UNKNOWN Primary Panel:Julie St-Pierre
Feb 16, 2015·European Journal of Internal Medicine·David S WaldJonathan P Bestwick

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Citations

Apr 9, 2016·Journal of Clinical Lipidology·Rolf Andersen, Lars Andersen
Apr 17, 2016·Journal of Biomedical Science·Raymond HendersonSteven Watterson
May 21, 2016·Nature Reviews. Endocrinology·Katrina L EllisGerald F Watts
Jun 5, 2016·Mayo Clinic Proceedings·Maya S Safarova, Iftikhar J Kullo
Apr 20, 2016·Current Opinion in Lipidology·Baris Gencer, David Nanchen
Jul 8, 2016·Nature Reviews. Cardiology·Peter J Schwartz, Federica Dagradi
Oct 12, 2016·Heart, Lung & Circulation·Alistair W Vickery, Gerald F Watts
Mar 3, 2017·Journal of Atherosclerosis and Thrombosis·Taro HaradaShinichi Oikawa
Nov 27, 2016·European Journal of Preventive Cardiology·Katrina L EllisGerald F Watts
May 4, 2017·Current Opinion in Lipidology·Colin A GrahamPadraig J Hart
Jul 19, 2017·European Journal of Preventive Cardiology·Gerald F Watts, Jing Pang
Dec 10, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Jian-Jun LiQian Dong
Nov 24, 2016·Clinical Chemistry·Roddy Walsh, Stuart A Cook
Mar 21, 2019·Annals of Clinical Biochemistry·L Renee RuhaakChrista M Cobbaert
Feb 24, 2016·Journal of Atherosclerosis and Thrombosis·Jing PangGerald F Watts
Jul 8, 2016·Journal of Atherosclerosis and Thrombosis·Gerald F WattsUNKNOWN for tha members of the "Ten countries Study"
May 26, 2018·Diabetologia·Christoph NowakJohan Ärnlöv
Nov 4, 2020·Journal of Clinical Medicine·Rebeca LorcaPablo Avanzas
Feb 17, 2021·Atherosclerosis. Supplements·Alessandro SionisJose L Zamorano
May 28, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ezimamaka AjufoDaniel J Rader
Aug 20, 2021·Therapeutic Advances in Chronic Disease·Chao XuanLi-Min Lun

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