Frequency of helicobacter pylori seropositivity and C-reactive protein increase in atrial fibrillation in patients undergoing coronary angiography

The American Journal of Cardiology
T Jared BunchSamuel J Asirvatham

Abstract

Atrial fibrillation (AF) is the most common rhythm disturbance seen in clinical practice. Evidence emerged that suggested inflammation was associated with risk of AF. Helicobacter pylori causes gastric and esophageal inflammation, as well as systemic and vascular inflammation. These local and systemic inflammatory effects may increase the risk of AF. Study patients were consecutive patients who underwent angiography for suspicion of coronary artery disease. Patients' AF status was determined by a search of hospital discharge summaries for diagnostic International Classification of Diseases, Ninth Revision codes for AF, assessment of previous electrocardiograms at the index and previous admissions to LDS Hospital (Salt Lake City, Utah), and search of the electrocardiographic database of LDS Hospital. In addition to routine laboratory studies, serum was analyzed to determine H pylori serostatus and index C-reactive protein (CRP) level. A total of 943 patients with known AF status were studied. Those with AF tended to be older (70.9 +/- 9.5 vs 63.9 +/- 10.7 years; p <0.001) and had a higher prevalence of congestive heart failure (28% vs 11%; p <0.001). In addition, patients with AF were more likely to be seropositive for H pylori ...Continue Reading

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Citations

May 13, 2011·Internal and Emergency Medicine·Francesco FranceschiRiccardo Fenici
Sep 12, 2008·Helicobacter·Hilde MoyaertAntonio Gasbarrini
Nov 18, 2016·International Journal of Environmental Research and Public Health·Jin YanGuoxin Zhang
Jan 21, 2012·Cardiology·Ayotunde Bamimore, Adam S Budzikowski
Jan 16, 2009·Journal of Cardiovascular Medicine·Monica LunettaSalvatore Novo
Feb 10, 2019·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Cecilia TettaSandro Gelsomino

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