[Frequency of hemoglobin abnormalities and hemoglobinopathies in Mozambique peoples (comparison between leprosy and non-leprosy subjects].

Blut
L NowickiH Martin

Abstract

In 588 bloodsamples of negride natives from Moçambique, preferably Chuabo and Macua, haemoglobin analyses were performed. In 21 cases an increase of Hb A2 was found, indicating the presence of heterozygous beta-thalassaemia, in one case the changes in Hb-analysis were typical for beta-delta-thalassaemia, 18 samples could be shown to contain Hb S, typical for the heterozygous sickle cell trait. Futhermore in 7 cases Hb A2' was found. In two bloodsamples haemoglobin variants were observed, which according to their electrophoretical mobility were assumed to represent Hb D in one case, and Hb G in the other. In the Chuabo population the frequency of the thalassaemia gene was found to be more than twice as high as in the Macua population. In non-lepers Hb S was observed with a remarkable higher incidence than in lepers.

References

Nov 1, 1953·Archives of Biochemistry and Biophysics·H A ITANO
Dec 12, 1959·Nature·K BETKEI SCHLICHT
Jan 1, 1964·Cold Spring Harbor Symposia on Quantitative Biology·A G MOTULSKY

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Citations

Apr 1, 1986·Journal of Medical Genetics·M C WillcoxS Bergström
Jan 1, 1977·Hemoglobin·F Vella

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