PMID: 18705425Aug 19, 2008Paper

Frequency of hepatomegaly and splenomegaly in Nigerian patients with sickle cell disease

West African Journal of Medicine
J A Olaniyi, U M Abjah

Abstract

Hepatobiliary and splenic complications (amongst others) are common in sickle cell disease (SCD) as a consequence of the progressive injury resulting from repeated sickling of HbS red blood cells. To determine the degree and the frequency of persistent hepatomegaly and splenomegaly in relation to determinants of clinical severity in patients with SCD. Two hundred and twenty SCD patients in clinical steady state were assessed for the presence and the size of palpably enlarged spleen and liver. Patients with hepatomegaly or splenomegaly were re-assessed after three months. Average size was recorded as well as the electrophoresis pattern, age at asessment, sex and the haematocrit. These were compiled over one year The mean age of the SCD patients was 24.7 (8.7) years. HbS and female subjects predominated, constituting 89% and 57% respectively. Females had statistically significantly higher mean age of years than males, (p < 0.001). Splenomegaly was present in 46 (21%) of SCD patients, of which 39 (84.8%) were HbSS, with a mean splenic size of 8.7 (7) cm. Out of the 220 SCD patients, hepatomegaly was present in 59%, with a mean size of 7.6 (6.5) cm. However, higher frequency and a significantly bigger size of hepatomegaly were foun...Continue Reading

Citations

May 22, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·I DiagneH D Sow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2022 Meta ULC. All rights reserved