Frequency of human immunodeficiency virus (HIV) infection among contemporary anti-HIV-1 and anti-HIV-1/2 supplemental test-indeterminate blood donors. The Retrovirus Epidemiology Donor Study

Transfusion
Michael P BuschG B Schreiber

Abstract

Follow-up studies from the mid-1980s showed that 1 to 5 percent of blood donors testing reactive in anti-human immunodeficiency virus type 1 (HIV-1) enzyme immunoassay (EIA) and testing indeterminate in Western blot were infected with HIV-1 and were in the process of seroconverting. The present study was conducted to establish the rate of HIV infection among contemporary anti-HIV-1/HIV type 2 (HIV-2) EIA-reactive, Western blot-indeterminate donors. Donations (n = 607) with indeterminate HIV supplemental test results were identified by screening 3,021,342 donations given from November 1990 through August 1993 at five participating blood centers. Consenting donors were enrolled and samples taken 4 to 8 weeks after donation. Follow-up sera were tested by EIA and Western blot for anti-HIV-1 seroconversion and by type-specific peptide assays for antibodies to HIV-2 and HIV-1 subtype O. Peripheral blood mononuclear cells and/or plasma from the follow-up samples were tested for HIV-1 DNA and/or RNA by polymerase chain reaction. The rate of HIV-1 infection among Western blot-indeterminate donors was also estimated by multiplying the incidence rate of HIV-1 seroconversion in this donor population by the estimated duration of the EIA-rea...Continue Reading

Associated Clinical Trials

Citations

Jan 5, 2002·Indian Journal of Pediatrics·N Choudhury, S Phadke
Aug 9, 2002·AIDS Research and Human Retroviruses·Barbara L ShacklettDouglas F Nixon
Feb 1, 2003·Transfusion·Usha K SharmaUNKNOWN Retrovirus Epidemiology Donor Study
Apr 20, 2001·Journal of Maxillofacial Surgery·Maria ChristopoulouIoannis Iatrou
Oct 25, 2020·BMC Public Health·P F BlatytaUNKNOWN NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) International Component, Brazil

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