Frequency of Immune Cell Subtypes in Peripheral Blood Correlates With Outcome for Patients With Metastatic Breast Cancer Treated With High-Dose Chemotherapy

Clinical Breast Cancer
Robert M LafrenieChristopher Shipp

Abstract

The frequency of circulating leukocytes has been shown to be a prognostic factor in patients being treated for different types of cancer. In breast cancer, tumor-infiltrating leukocytes may predict patient outcome, but few studies have investigated such associations for circulating leukocytes. Multiparametric flow cytometry was used to examine the immunophenotypes of circulating peripheral blood mononuclear cells for 88 patients with metastatic breast cancer, which was then correlated to breast cancer-specific survival. Patients had been treated either with high-dose cyclophosphamide-containing regimens (group 1, n = 51 patients) or high-dose paclitaxel-containing regimens (group 2, n = 37 patients). The frequency of peripheral blood CD14+ monocytes indicated prognosis for patients in group 1 (but not group 2), while higher levels of CD11c+ dendritic cells indicated a better prognosis for patients in group 2 (but not group 1). The frequency of a number of different CD4+ or CD8+ T cell subtypes also predicted prognosis for patients in group 2. For example, patients in group 2 with a higher frequency of circulating CD4+ or CD8+ naive T cells (CD45RA+CD95-CD27+CD28+) showed a poorer prognosis. In contrast, T cells were not associa...Continue Reading

References

Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S GlückG Gallant
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
Mar 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pedro RomeroNathalie Rufer
Jul 19, 2008·International Immunology·Ryo OkadaMasafumi Takiguchi
Mar 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicola J BoothMilica Vukmanovic-Stejic
Apr 12, 2011·Cell Communication and Signaling : CCS·Maren Paulsen, Ottmar Janssen
Jan 31, 2012·Human Immunology·Ilaria TraversoGilberto Filaci
Apr 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin WeideGraham Pawelec
Jan 30, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexandra SevkoViktor Umansky
Feb 27, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jinpu YuXiubao Ren
May 9, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dominic E SanfordDavid C Linehan
May 16, 2013·The Journal of Investigative Dermatology·Jürgen C Becker, David Schrama
Jul 6, 2013·Breast Cancer Research and Treatment·Joseph MarkowitzWilliam E Carson
Dec 11, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin WeideGraham Pawelec
Jun 19, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Henning ZelbaGraham Pawelec
Jan 21, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander MartensBenjamin Weide
May 14, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander MartensBenjamin Weide
May 29, 2016·Journal of Translational Medicine·Jithendra Kini BailurGraham Pawelec
May 30, 2016·Cellular and Molecular Life Sciences : CMLS·Christopher ShippGraham Pawelec
Jul 31, 2016·Journal of Translational Medicine·M MiyanJ de Boniface
Sep 21, 2016·Cancer Chemotherapy and Pharmacology·Martina Ahlmann, Georg Hempel
Oct 26, 2016·Journal for Immunotherapy of Cancer·Sasha E Stanton, Mary L Disis
Dec 4, 2016·Breast Cancer Research and Treatment·Yul Ri ChungSo Yeon Park
Feb 9, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kilian Wistuba-HamprechtBenjamin Weide
Mar 12, 2017·Cancer Immunology, Immunotherapy : CII·Salman M ToorEyad Elkord
Apr 22, 2017·Journal for Immunotherapy of Cancer·Sotirios P FortisConstantin N Baxevanis
Jul 9, 2017·Cancer Immunology, Immunotherapy : CII·Robert WesolowskiWilliam E Carson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.