PMID: 9537399Apr 16, 1998Paper

Frequency of pilin antigenic variation in Neisseria gonorrhoeae

Journal of Bacteriology
C D Serkin, H S Seifert

Abstract

Variation of the pilus of Neisseria gonorrhoeae occurs by the recombination of silent pilin DNA sequences into the pilin expression locus. We have developed a quantitative, competitive reverse transcription-PCR assay which measures the frequency of pilin antigenic variation independently of changes in gonococcal colony morphology and have determined this frequency within a gonococcal population. We have also studied the frequency of antigenic variation during growth and have concluded that growth does not dramatically influence the frequency of pilin antigenic variation, although a reproducible, twofold increase is observed upon the transition into late log/stationary phase.

References

May 1, 1976·Journal of Bacteriology·T ElmrosG D Bloom
Jun 1, 1979·Journal of Bacteriology·L NorlanderS Normark
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A B JonssonS Normark
Jun 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Q Y ZhangM Koomey
Jun 1, 1990·The Journal of Experimental Medicine·J SwansonS Hill
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E SegalM So
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S BergströmJ Swanson
Apr 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·S A Morse, L Bartenstein
Jun 1, 1994·The Journal of Clinical Investigation·H S SeifertJ G Cannon
Jul 1, 1994·Molecular Microbiology·L A WainwrightH S Seifert
Mar 1, 1997·Molecular Microbiology·I J Mehr, H S Seifert
Jun 1, 1963·Journal of Bacteriology·D S KELLOGGD I PIRKLE

❮ Previous
Next ❯

Citations

Feb 10, 2012·Journal of Biomedicine & Biotechnology·Luis VelasquezHugo Cardenas
Sep 6, 2000·Molecular Microbiology·C D Serkin, H S Seifert
Feb 3, 2005·Journal of Bacteriology·Eric P SkaarAnna C Karls
Jun 9, 2009·Nature Reviews. Microbiology·Kirk W DeitschJames R Stringer
Jul 7, 2016·Journal of Bacteriology·Ella RotmanH Steven Seifert
Jul 16, 2002·Infection and Immunity·Paola SalvatorePietro Alifano
Jun 15, 2007·Infection and Immunity·Johanna K HansenKatrina T Forest
Jan 4, 2012·FEMS Microbiology Reviews·Cornelis VinkH Steven Seifert
Sep 25, 2014·Annual Review of Genetics·Ella Rotman, H Steven Seifert
Feb 13, 2001·Journal of Bacteriology·C D LongH S Seifert
Oct 1, 2005·Molecular Microbiology·Alison K CrissH Steven Seifert
Jul 14, 2009·Journal of Bacteriology·R Allen Helm, H Steven Seifert
Sep 28, 1999·Journal of Bacteriology·B Howell-Adams, H S Seifert
Mar 15, 2006·The Journal of Biological Chemistry·Michael P Killoran, James L Keck
Jul 25, 2019·Journal of Bacteriology·Mariya LobanovskaRachel M Exley
Aug 17, 2019·Biochemical and Biophysical Research Communications·Debika Ojha, K Neelakanteshwar Patil
Oct 19, 2017·Pathogens and Disease·Cynthia Nau Cornelissen
Feb 28, 2002·Journal of Molecular Biology·David T Pride, Martin J Blaser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.