Frequency of polycythemia in individuals with normal complete blood cell counts according to the new 2016 WHO classification of myeloid neoplasms

International Journal of Laboratory Hematology
A F SandesM de L Chauffaille

Abstract

Polycythemia vera (PV) is a disorder characterized by clonal proliferation of myeloid cells and increased red blood cell mass. Recently, the revised 2016 WHO classification of myeloid neoplasms decreased the threshold levels of hemoglobin and hematocrit for the diagnosis of PV. However, the new proposed cutoffs have remarkable overlap with the normal reference values reported and the clinical impact of these new cutoffs has not been widely assessed in the general population. We retrospectively examined 248 839 patients with presumptively normal complete blood cell results, consecutively obtained in an outpatient setting. The proportion of men with Hb >165 g/L was 5.99%, Hct>49% was 2.4%, and Hb >165 g/dL or Hct>49% was 6.48%, while the proportion of women with Hb >160 g/L was 0.22%, Hct>48% was 0.11%, and Hb >160 g/L or Hct>48% was 0.28%. The isolated use of the proposed Hb/Hct levels as a definer of polycythemia may lead to a substantial increase in unnecessary diagnostic tests. In cases with borderline levels of hemoglobin, the diagnostic workup of PV should only be indicated in the presence of clinical and/or laboratorial features associated with MPN.

References

Jan 1, 1992·European Journal of Haematology·S Berglund, O Zettervall
Jan 1, 1997·The American Journal of Medicine·T LamyP Y Le Prise
Jun 6, 2003·British Journal of Haematology·Barbara J Bain
Jul 21, 2005·British Journal of Haematology·Mary F McMullinUNKNOWN General Haematology Task Force of the British Committee for Standards in Haematology
May 5, 2006·Seminars in Thrombosis and Hemostasis·Peter Johansson
Aug 4, 2007·British Journal of Haematology·Mary F McMullinUNKNOWN British Committee for Standards in Haematology
Nov 3, 2009·Journal of Zhejiang University. Science. B·Justyna KwapiszJoanna Jasiniewska
Sep 3, 2013·American Journal of Hematology·Tiziano BarbuiAyalew Tefferi
Oct 30, 2013·American Journal of Hematology·Tiziano BarbuiAyalew Tefferi
Feb 19, 2014·American Journal of Hematology·Tiziano BarbuiAyalew Tefferi

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Citations

Jun 9, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M RehakP Wiedemann
May 23, 2021·International Journal of Hematology·Kristell MaheJean-Christophe Ianotto

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