PMID: 8967705Dec 15, 1996Paper

Frequency of pregnancy-related venous thromboembolism in anticoagulant factor-deficient women: implications for prophylaxis

Annals of Internal Medicine
P W FriederichM H Prins

Abstract

It has been reported that women with an inherited deficiency of antithrombin, protein C, or protein S have an increased risk for developing venous thromboembolic disease during pregnancy and the postpartum period. However, because the available data on risk are flawed, it is difficult to define a rational, efficacious, and safe policy about prophylaxis for venous thromboembolism in these women. To determine the frequency of venous thromboembolism during pregnancy and the postpartum period in women with heritable deficiencies of anticoagulant factors. Retrospective cohort study. University outpatient clinics in the Netherlands and Italy. 129 otherwise asymptomatic female family members of patients with a history of venous thromboembolism and an established deficiency of antithrombin, protein C, or protein S. Medical history, with specific attention to episodes of venous thromboembolism and obstetric history, was taken. The anticoagulant factor status of the study participants was determined. If a patient had an episode of venous thromboembolism, subsequent pregnancies in that patient were not analyzed. Of the 129 women who participated in the study, 60 had anticoagulant factor deficiency and 69 did not. In the nondeficient group...Continue Reading

Citations

Feb 23, 2011·Journal of Thrombosis and Thrombolysis·Saskia Middeldorp
Mar 18, 2009·Current Treatment Options in Cardiovascular Medicine·Marcelo P Villa-Forte Gomes
Jun 14, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Alberto RomeroMiguel-Angel González
Jan 6, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jordi SabadellLuis Cabero
Feb 20, 2003·Thrombosis Research·Shannon M Bates
Apr 20, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D VinatierJ L Houpeau
Jul 20, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Amiram Eldor
Mar 28, 1998·Neurologic Clinics·J GilmoreB J Stern
Sep 27, 2000·Hematology/oncology Clinics of North America·L HeilmannG F von Tempelhoff
May 24, 2003·Best Practice & Research. Clinical Haematology·Marc A RodgerPhilip S Wells
May 24, 2003·Best Practice & Research. Clinical Haematology·Rainer B ZotzRüdiger E Scharf
Jun 6, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Louise Bowles, Hannah Cohen
Jun 14, 2001·British Journal of Haematology·S MiddeldorpH R Büller
Sep 13, 2001·British Journal of Haematology·UNKNOWN Haemostasis and Thrombosis Task Force, British Committee for Standards in Haematology
Apr 20, 2001·The New England Journal of Medicine·U Seligsohn, A Lubetsky
Apr 29, 1998·Current Opinion in Obstetrics & Gynecology·J Girling, M de Swiet
Feb 27, 1999·Current Opinion in Obstetrics & Gynecology·E C Grendys, J V Fiorica
Dec 22, 1999·Obstetrical & Gynecological Survey·C J Lockwood
Jul 17, 1999·Current Opinion in Pulmonary Medicine·M D McCollI A Greer
Jul 17, 1999·Current Opinion in Pulmonary Medicine·K A Valentine
Aug 5, 2006·Current Opinion in Hematology·Jean-Christophe GrisPierre Marès
Apr 5, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Elvira GrandoneMaurizio Margaglione
Nov 14, 2006·Postgraduate Medical Journal·L Merriman, M Greaves
Apr 25, 2000·Annual Review of Medicine·C KearonJ Hirsh
Nov 18, 2003·Reproductive Biology and Endocrinology : RB&E·Michael J Kupferminc
Apr 21, 1999·Lancet·F R Rosendaal
May 22, 2013·Journal of Thrombosis and Thrombolysis·E ContiM Volpe
Apr 29, 2014·Blood Reviews·Suzanne M BlekerSaskia Middeldorp
Feb 21, 2014·Journal of Women's Health·Whitney D MaxwellCharles L Bennett
Mar 1, 2007·Women's Health·Rainer B ZotzRüdiger E Scharf
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M A Okon, S F Spooner
Jan 19, 2016·Journal of Thrombosis and Thrombolysis·Shannon M BatesIan Greer
Sep 11, 2012·Best Practice & Research. Clinical Haematology·Anne Flem Jacobsen, Per Morten Sandset
Feb 7, 2001·Chest·J S GinsbergJ Hirsh
Feb 9, 2012·Primary Care·Lee T Dresang, Lawrence Leeman
Nov 16, 2011·Critical Care Clinics·Julia A M Anderson, Jeffrey I Weitz
Oct 18, 2011·Seminars in Hematology·Shannon M Bates
Nov 5, 2010·Clinics in Chest Medicine·Julia A M Anderson, Jeffrey I Weitz
Jul 20, 2010·Clinics in Laboratory Medicine·Jeanine F Carbone, Roxane Rampersad
Aug 13, 2009·Thrombosis Research·Federico LussanaUNKNOWN Italian Society for Haemostasis and Thrombosis
Aug 30, 2008·The Medical Clinics of North America·Michael P Carson, Deborah Ehrenthal
Dec 20, 2007·Oral and Maxillofacial Surgery Clinics of North America·Brett A Ueeck, Leon A Assael
Aug 2, 2013·Thrombosis and Haemostasis·K BramhamB J Hunt

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