Frequency of primary amenorrhea due to chromosomal aberration

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Shazia Jabbar

Abstract

To find out the frequency of primary amenorrhea due to chromosomal aberration and the different options available for management. Non-interventional study. The study was conducted over a period of two years from April 1999 to March 2001 in Gynaecology and Obstetrics Department, Unit-I, Civil Hospital, Karachi. All patients with primary amenorrhea due to chromosomal aberrations were included in study. Patient's detailed history, general physical examination, presence or absence of secondary sexual characteristics, abdominal and pelvic examination finding were noted. Targeted investigations, including ultrasound, hormonal assay, buccal smear and karyotyping, results were recorded. The management options were individually tailored with focus on psychological management. Eighteen patients out of 30,000 patients were diagnosed as having primary amenorrhea. Six had primary amenorrhea due to chromosomal aberrations with the frequency of 0.02%. The age at presentation was 20 years and above in 50%. The most common cause was Turner's syndrome seen in 4 out of 6. The presenting symptoms were delay in onset of menstruation in 05 patients and primary infertility in 01 patient. Primary amenorrhea due to chromosomal aberration is an uncommon...Continue Reading

Citations

Jun 17, 2011·Human Reproduction·G Lambert-MesserlianS T McGarvey
Jul 21, 2011·Journal of Human Reproductive Sciences·Seema KorgaonkarBabu Rao Vundinti

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