PMID: 7546905Jul 1, 1995Paper

Frequency of provirus-bearing CD4+ cells in HIV type 1 infection correlates with extent of in vitro apoptosis of CD8+ but not of CD4+ cells

AIDS Research and Human Retroviruses
M CarbonariM Fiorilli

Abstract

Lymphocytes from HIV-1-infected subjects undergo massive apoptosis when cultured in vitro, and this phenomenon might reflect pathogenetic mechanisms leading to immune dysfunction in vivo. However, (1) lymphocyte death is not restricted to CD4+ cells but seems to involve predominantly CD8+ cells, and (2) the same phenomenon occurs in other viral infections. Furthermore, it is not known whether a relationship exists between the HIV-1 burden and this type of cell death. In this work we sought to determine whether the HIV-1 provirus load correlates with the propensity to apoptosis of CD4+ and CD8+ cells. We studied 10 HIV-1-infected patients with CD4+ cell counts above 500/mm3 and free of concomitant infections. We correlated the frequency of HIV-1-infected CD4+ cells with the extent of culture-induced apoptosis as well as with the phenotype of the apoptotic lymphocytes. We found that the magnitude of apoptosis correlated with the frequency of HIV-1-infected CD4+ cells (p = 0.0007), and that increasing viral load and apoptosis were associated with a shift to the selective death of CD8+ cells. Our data support the view that, in addition to CD4+ cell killing, another immunopathogenic effect of HIV might be that of priming CD8+ cells ...Continue Reading

References

Jul 10, 1992·Science·L MeyaardF Miedema
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Citations

Jan 1, 1997·Springer Seminars in Immunopathology·L Meyaard, F Miedema
Jun 25, 2004·Retrovirology·Barbara AhrMartine Biard-Piechaczyk
Apr 21, 2001·Cell Death and Differentiation·N Selliah, T H Finkel
Jan 8, 1999·Virology·E RapaportT H Finkel
Dec 1, 1996·Microbiological Reviews·K F Copeland, J L Heeney

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis