Frequency of R factor-mediated multiple drug resistance in Klebsiella and Aerobacter.

Applied Microbiology
V HinshawH P Dalton

Abstract

A comparative study was done on the transfer frequency of R factors from 90 strains of multiple drug-resistant Aerobacter and 81 strains of Klebsiella to Escherichia coli CSH-2 (F(-), met(-), pro(-), Nal-r). The most common resistance patterns for the Aerobacter isolants were ampicillin streptomycin chloramphenicol tetracycline and ampicillin streptomycin chloramphenicol tetracycline kanamycin neomycin; for the Klebsiella isolants, the most common resistance pattern was ampicillin kanamycin streptomycin tetracycline chloramphenicol neomycin. R factors were isolated from 14.1% of the Aerobacter strains; 61.5% of these R factors harbored R determinants for ampicillin streptomycin tetracycline. R factors were isolated from 79.1% of the Klebsiella strains; four R factors were isolated with significant frequency; streptomycin chloramphenicol kanamycin neomycin, 37.5%; ampicillin streptomycin tetracycline kanamycin neomycin, 14.1%; ampicillin streptomycin tetracycline, 12.5%; and streptomycin chloramphenicol tetracycline, 12.5%.Chloramphenicol, kanamycin, and neomycin resistance was rarely transferred from the Aerobacter strains, although over 50% of the clinical isolants possessed resistance to these antibiotics. In contrast, over 7...Continue Reading

References

Jul 1, 1967·Applied Microbiology·H P Dalton, M J Allison
Dec 1, 1967·Annals of Internal Medicine·W E Farrar, L C Dekle
Sep 1, 1965·British Medical Bulletin·N Datta
Nov 1, 1965·The American Journal of Medicine·F A Gill, E W Hook
Jan 1, 1968·Journal of General Microbiology·M DemerecP E Hartman
Aug 4, 1966·The New England Journal of Medicine·S A Kabins, S Cohen
Mar 1, 1963·Bacteriological Reviews·T WATANABE

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Citations

Dec 1, 1980·Antimicrobial Agents and Chemotherapy·M A CourtneyU N Streips
Jan 1, 1987·Applied and Environmental Microbiology·M V WalterR J Seidler
Aug 1, 1981·Applied and Environmental Microbiology·J L ArmstrongR J Seidler

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