Frequency of respiratory viruses among patients admitted to 26 Intensive Care Units in seven consecutive winter-spring seasons (2009-2016) in Northern Italy

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
Antonio PirallaFausto Baldanti

Abstract

The role of respiratory viruses in the etiology of community-acquired pneumonia (CAP) is still debated. The advent of molecular assays has improved the identification of viruses in patients with CAP and according to published studies, viruses account for 11-55% of adult CAP cases. In the present study, the frequency of respiratory viruses was evaluated in respiratory samples collected from 414 patients with CAP admitted to 26 ICUs in the Lombardy Region (10 million inhabitants) during seven winter-spring seasons (2009-2016). In 226 (54.6%) patients one or more respiratory viruses were identified, while 188 (45.4%) patients were negative. A single virus infection was observed in 214/226 (94.7%) patients; while, in 12/226 (5.3%) at least two respiratory viruses were detected. Influenza A was the most common virus in 140/226 patients (61.9%) followed by rhinoviruses (33/226, 14.6%), respiratory syncytial virus (13/226, 5.8%), influenza B virus (9/226, 4.0%), human coronaviruses (9/226, 4.0%), cytomegalovirus (9/226, 4.0%) and human metapneumovirus (1/226, 0.4%). Viral infections are present in a consistent proportion of patients admitted to the ICU for CAP. Influenza A and rhinovirus accounted for three-quarters of all CAP in ICU ...Continue Reading

Citations

Sep 13, 2019·Clinical Microbiology Reviews·Michael G Ison, Hans H Hirsch
Aug 12, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Tobias RachowMarie von Lilienfeld-Toal
Sep 6, 2018·BMC Infectious Diseases·Jessica QuahThean Yen Tan
May 16, 2020·Influenza and Other Respiratory Viruses·Susana MongeLiselotte van Asten
Dec 2, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Michael KlompasMichael B Rothberg
Feb 20, 2021·The Journal of Antimicrobial Chemotherapy·Svetlana RachinaUlyana Portnyagina
Dec 11, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Runan ZhuYuan Qian

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