Frequency of silent brain lesions and aspirin protection evaluation over 3 years follow-up in beta thalassemia patients

Annals of Hematology
Mehran KarimiSanaz Safaei

Abstract

Silent brain lesions might be associated with overt cerebrovascular accident over time in beta thalassemia major (BTM) and intermediate (BTI). Aspirin may be protective in these patients. We evaluated brain magnetic resonance imaging (MRI) in thalassemia patients to see whether aspirin is protective or not. A historical cohort study was conducted on 35 thalassemia patients, 22 BTI, and 13 BTM patients at Shiraz Hematology Research Center in 2018. Median age of the patients was 32 years and ranged from 8 to 42 years. Twenty-four patients (68.6%) were females. Overall frequency of white matter lesions (WMLs) in the first MRI was 10 patients (28.6%). After 3 years, 3 patients developed new lesions and the frequency of WMLs was 13 patients (37.1%) in the second MRI. Moreover, in 3 patients, number of WMLs increased. Patients with new lesions or more lesions compared to the baseline were significantly older than the other group (median age 36.5 years vs. 31 years, P = 0.046). Regarding aspirin consumption, only 1 patient (16.7%) of patients with new lesions was using aspirin compared to 10 (34.5%) of the other group (P = 0.640). The high-risk patients with thrombocytosis, splenectomy, severe iron overload, and older age (> 30 years)...Continue Reading

References

May 1, 1990·Stroke; a Journal of Cerebral Circulation·V WongT K Chan
Apr 29, 1998·Acta Haematologica·C Borgna PignattiS Musumeci
May 5, 2000·The Cochrane Database of Systematic Reviews·G GubitzC Counsell
Jan 5, 2002·Blood·Amiram Eldor, Eliezer A Rachmilewitz
Jun 14, 2003·The Cochrane Database of Systematic Reviews·P SandercockC Counsell
Apr 1, 2006·Brain & Development·Dimitrios I ZafeiriouMiranta Athanasiou-Metaxa
Aug 19, 2007·American Journal of Hematology·Mehran KarimiEliezer A Rachmilewitz
Jan 1, 2008·Archives of Medical Research·Mehran KarimiEliezer Rachmilewitz
May 31, 2008·Blood Reviews·Ali T TaherMaria D Cappellini
Oct 13, 2009·Journal of Thrombosis and Haemostasis : JTH·A T TaherA Beydoun
Aug 18, 2010·Annals of the New York Academy of Sciences·Eitan Fibach, Eliezer A Rachmilewitz
Feb 11, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Sezaneh Haghpanah, Mehran Karimi
Mar 7, 2012·Current Treatment Options in Cardiovascular Medicine·Noorjahan AliSteven Pavlakis
Jul 25, 2012·Annals of Hematology·Mehran KarimiEliezer A Rachmilewitz
Sep 24, 2014·Pediatric Hematology and Oncology·Mehran KarimiAli Taher
Sep 24, 2015·Annals of Hematology·Mehran KarimiEliezer A Rachmilewitz

❮ Previous
Next ❯

Citations

Jul 6, 2020·Annals of Hematology·Antoine N SalibaAli T Taher
Jul 27, 2021·Frontiers in Immunology·Esha SehanobishElina Jerschow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

© 2021 Meta ULC. All rights reserved