PMID: 9437266Jan 23, 1998Paper

Frequency of spontaneous congenital defects in rhesus and cynomolgus macaques

Journal of Medical Primatology
P E PetersonA G Hendrickx

Abstract

This paper summarizes the spontaneous incidence of congenital defects in the rhesus and cynomolgus macaque colonies (Macaca mulatta and M. fascicularis) at the California Regional Primate Research Center. The computerized database used in this analysis included fetuses, term infants, juveniles, and adults that underwent a necropsy procedure over a 14-year period (1983-1996). The calculated malformation rates were 0.9% (40/4,390) and 0.3% (3/965) for the rhesus and cynomolgus monkey, respectively. Most of the observed malformations in both species affected the musculoskeletal and the cardiovascular systems, while a smaller number of defects were observed in the gastrointestinal, urogenital, endocrine, and central nervous systems. Inbreeding did not contribute to the spontaneous malformation incidence and there was no predilection for sex (male vs. female) or housing (indoors vs. outdoors) among the malformed cases. This spontaneous malformation database in our macaque colony aids in the interpretation of defects that occur in an experimental study as well as in the ongoing assessment of a healthy nonhuman primate breeding colony.

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Citations

Dec 7, 2000·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·X WeiA G Hendrickx
Feb 18, 2014·Journal of Comparative Pathology·S LangerK Mätz-Rensing
Dec 23, 2014·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Sabrina KriefGérard Couly
May 3, 2012·American Journal of Primatology·Sarah E TurnerMasayuki Nakamichi
May 14, 2011·American Journal of Medical Genetics. Part a·Charleen M MooreMichael D Davis
Feb 22, 2011·Journal of Medical Primatology·Benjamin FoxEdward J Dick
Dec 22, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Gary J ChellmanGerhard F Weinbauer
Jun 15, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Philip JarvisGerhard F Weinbauer
Jan 14, 2012·Systems Biology in Reproductive Medicine·Ali S Faqi
Sep 20, 2007·Folia primatologica; international journal of primatology·Michelle L Sauther, Frank P Cuozzo
Jul 12, 2002·Journal of Medical Primatology·L BrignoloA G Hendrickx
Mar 8, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Timothy K Cooper, Kathleen L Gabrielson
Jan 10, 2003·Journal of Medical Primatology·E F IsachenkoH W Michelmann
Dec 2, 2017·Journal of Medical Primatology·Hallie Mason Smith Lloyd, Claire A Kirchhoff
Mar 7, 2021·Journal of Medical Primatology·Rebecca L SmithPaul Smith

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