Frequency of the basal-like phenotype in African breast cancer

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
Hawa NalwogaLars A Akslen

Abstract

Basal-like breast carcinoma has been recognized as a subtype with specific prognostic implications. However, there is a lack of reports about this category of breast tumors in African women. The aim of this study was to explore the basal-like phenotype in breast cancer patients in an African population, and a registry-based series was included from the well-defined Kyadondo County in Uganda (1.7 millions). We studied a total of 65 archival paraffin blocks of invasive breast cancer using antibodies against cytokeratin 5/6 and P-cadherin, and these markers were expressed in 34% of all cases and in 52% of ER (estrogen receptor)-negative tumors. All basal-like tumors were ER negative (p<0.0005) and PR (progesterone receptor) negative (p=0.002). Basal-like breast carcinomas were of a higher histologic grade (p=0.001), had high mitotic counts (p=0.002), and marked nuclear pleomorphism (p=0.002). P-cadherin-positive tumors had a high Ki-67 proliferative rate (p=0.039). In conclusion, the basal-like phenotype is frequent in this African series of breast cancer and is strongly associated with poor prognostic factors. Our findings might be significant in relation to clinical management of these patients, including novel targeted therapy.

References

Feb 1, 1989·The British Journal of Surgery·A A OtuE B Attah
Apr 17, 1998·JAMA : the Journal of the American Medical Association·B NewmanM C King
Jun 11, 1999·The British Journal of Surgery·C A Adebamowo, O O Adekunle
Jul 27, 1999·American Journal of Human Genetics·H C MeffordF Arena
Aug 17, 1999·International Journal of Cancer. Journal International Du Cancer·P PisaniJ Ferlay
Sep 10, 1999·Human Genetics·R C PanguluriG M Dunston
Aug 30, 2000·Nature·C M PerouD Botstein
Oct 31, 2000·International Journal of Cancer. Journal International Du Cancer·F SitasV Beral
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Aug 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·O F IkpattY Collan
Dec 6, 2002·The American Journal of Pathology·Matt van de RijnPat Brown
Mar 26, 2003·Archives of Pathology & Laboratory Medicine·Alfredo Ribeiro-SilvaSérgio Zucoloto
Apr 22, 2003·Pathology Oncology Research : POR·Alfredo Ribeiro-SilvaSérgio Zucoloto
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Aug 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Christos SotiriouEdison T Liu
Oct 2, 2003·Journal of the National Cancer Institute·William D FoulkesLars A Akslen
Mar 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ingunn M StefanssonLars A Akslen
May 14, 2004·The Journal of Pathology·Dalia M Abd El-RehimIan O Ellis
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Karin CollettLars A Akslen
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jarle B ArnesWilliam D Foulkes
Jul 14, 2005·Virchows Archiv : an International Journal of Pathology·Irina MatosFernando Schmitt
Dec 13, 2005·Critical Reviews in Oncology/hematology·Marzia PalmaAlberto Gulino
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Socorro María Rodríguez-PinillaJosé Palacios
Apr 22, 2006·American Journal of Clinical Pathology·Alfredo Ribeiro-SilvaSérgio Zucoloto
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Mar 1, 1981·International Journal of Andrology·R C B Pugh, Constance Parkinson

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Citations

May 4, 2010·Breast Cancer Research and Treatment·Barbara K DunnKaren A Johnson
Aug 1, 2013·Breast Cancer Research and Treatment·M J EngstrømA M Bofin
Sep 21, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gulisa TurashviliSamuel A J R Aparicio
Dec 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Katie M O'BrienRobert C Millikan
Dec 1, 2014·BMC Cancer·Eva Johanna KantelhardtBekuretsion Yonas
Jan 29, 2011·Pathology Research International·Khalid Dafaallah AwadelkarimRenato Mariani-Costantini
Aug 30, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hawa NalwogaLars A Akslen
Jul 15, 2011·The Breast Journal·Mateya E TrinkausYasmin Rahim
Jan 3, 2013·International Journal of Cancer. Journal International Du Cancer·Neill PataniMitch Dowsett
May 27, 2015·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lavina AhmedLars A Akslen
Oct 14, 2014·Archives of Pathology & Laboratory Medicine·Damoun Safarpour, Fattaneh A Tavassoli
Jun 27, 2017·Annals of Diagnostic Pathology·Aziza E AbdelrahmanMohamed I Abdelhamid
Sep 23, 2018·Journal of Global Oncology·Asmerom Tesfamariam SengalEva Johanna Kantelhardt
Feb 3, 2011·Archives of Pathology & Laboratory Medicine·Indrojit Roy, Emmanuel Othieno
Sep 19, 2020·BMJ Supportive & Palliative Care·Runzhi QiQiujun Guo

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