Frequency of Val1016Ile mutation in the voltage-gated sodium channel gene of Aedes aegypti Brazilian populations

Tropical Medicine & International Health : TM & IH
Ademir Jesus MartinsDenise Valle

Abstract

One of the major insect pyrethroid resistance mechanisms affects its target site, the voltage-gated sodium channel (Na(v)). In Aedes aegypti, the Val1016Ile substitution of the AaNa(v) gene is associated to resistance in several Latin American countries. Genotyping of susceptible and resistant mosquitoes from seven Brazilian localities detected the 1016Ile mutation in five populations with a higher frequency of this substitution in resistant specimens in all cases. Furthermore, analysis of nine additional field populations revealed that five also presented the 1016Ile mutation. Our data suggest a recent dissemination and involvement of this substitution with pyrethroid resistance in Brazil.

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Citations

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Dec 21, 2017·The American Journal of Tropical Medicine and Hygiene·Andrea Gloria-SoriaJeffrey R Powell
May 1, 2019·Memórias do Instituto Oswaldo Cruz·Denise ValleAdemir de Jesus Martins Junior
Apr 17, 2020·PLoS Neglected Tropical Diseases·Luciano Veiga CosmeAdemir Jesus Martins
Apr 18, 2020·PLoS Neglected Tropical Diseases·Yinjun FanJeffrey G Scott
May 8, 2020·Archives of Insect Biochemistry and Physiology·Mengli ChenKe Dong
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Nov 19, 2020·PLoS Neglected Tropical Diseases·Helio SchechtmanMax O Souza

Related Concepts

Aedes
Genetic Equilibrium
Insecticide Resistance
Insecticides
Pyrethroids
Sodium Channel
Nested Polymerase Chain Reaction
Oligonucleotide Primers
Amino Acid Substitution
Genes