Frequency-Specific Resting Connectome in Bipolar Disorder: An MEG Study

Frontiers in Psychiatry
Masakazu SunagaMasato Fukuda

Abstract

Bipolar disorder (BD) is a serious psychiatric disorder that is associated with a high suicide rate, and for which no clinical biomarker has yet been identified. To address this issue, we investigated the use of magnetoencephalography (MEG) as a new prospective tool. MEG has been used to evaluate frequency-specific connectivity between brain regions; however, no previous study has investigated the frequency-specific resting-state connectome in patients with BD. This resting-state MEG study explored the oscillatory representations of clinical symptoms of BD via graph analysis. In this prospective case-control study, 17 patients with BD and 22 healthy controls (HCs) underwent resting-state MEG and evaluations for depressive and manic symptoms. After estimating the source current distribution, orthogonalized envelope correlations between multiple brain regions were evaluated for each frequency band. We separated regions-of-interest into seven left and right network modules, including the frontoparietal network (FPN), limbic network (LM), salience network (SAL), and default mode network (DMN), to compare the intra- and inter-community edges between the two groups. In the BD group, we found significantly increased inter-community ed...Continue Reading

References

Feb 1, 1989·IEEE Transactions on Bio-medical Engineering·M S Hämäläinen, J Sarvas
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Apr 19, 2003·Psychological Medicine·J T O CavanaghS M Lawrie
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Jun 26, 2004·Science·György Buzsáki, Andreas Draguhn
Sep 24, 2004·Brain Topography·Samu TauluJuha Simola
Sep 6, 2005·Brain : a Journal of Neurology·Marco Catani, Dominic H ffytche
Nov 3, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Danielle Smith Bassett, Ed Bullmore
Dec 26, 2006·NeuroImage·N Hironaga, A A Ioannides
Mar 30, 2007·Bipolar Disorders·A Martinez-AranJ L Ayuso-Mateos
Jul 9, 2008·Current Opinion in Neurology·Michael Greicius
Oct 1, 2008·Neuroscience and Biobehavioral Reviews·Samantha J BroydEdmund J S Sonuga-Barke
Mar 31, 2009·Journal of Psychopharmacology·G M Goodwin, UNKNOWN Consensus Group of the British Association for Psychopharmacology
Jun 6, 2009·Current Opinion in Neurology·Danielle S Bassett, Edward T Bullmore
Apr 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giacomo SalvadoreCarlos A Zarate
Jul 2, 2010·Frontiers in Systems Neuroscience·Michael D Fox, Michael Greicius
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Jun 10, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaoqian J ChaiDost Ongür
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew J BrookesPeter G Morris
Dec 29, 2011·Frontiers in Bioscience (Elite Edition)·Josselin HouenouMichele Wessa
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
May 9, 2012·Nature Neuroscience·Joerg F HippAndreas K Engel
May 29, 2012·Bipolar Disorders·Stephen M StrakowskiJennifer D Townsend
May 7, 2013·NeuroImage·Alex FornitoMichael Breakspear
Jul 9, 2013·Journal of Affective Disorders·Cristian VargasEduard Vieta
Oct 2, 2013·Indian Journal of Psychiatry·Maurizio PompiliPaolo Girardi
Oct 29, 2013·NeuroImage·Alexandre GramfortMatti S Hämäläinen
Nov 2, 2013·NeuroImage. Clinical·Dae-Jin KimBrian F O'Donnell
May 13, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Naruhito HironagaShozo Tobimatsu
Jun 2, 2014·The American Journal of Psychiatry·Gordon Parker
Jul 30, 2014·Biological Psychiatry·Manfred G KitzbichlerTal Kenet
Jan 21, 2015·Psychiatry and Clinical Neurosciences·Toshiya Inada, Ataru Inagaki
Sep 22, 2015·Lancet·Iria GrandeEduard Vieta
Oct 9, 2015·Physics in Medicine and Biology·George C O'NeillMatthew J Brookes

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

FreeSurfer
SciPy
MNE
Isotrak

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.