Abstract
Since the mortality rate for childhood differentiated thyroid carcinoma is nearly zero, the focus must be to minimise morbidity following treatment. Our aim was to analyse early and late adverse events. Twenty-five of 26 children treated between 1962 and 2002 were evaluated. Median follow-up was 14.2 years (range 0.9-39.4 years). All underwent total thyroidectomy, 15 (60%) with lymph node dissection and 15 (60%) with adjuvant radio-iodide therapy. Mortality was zero. Seven developed recurrent disease, two developed a third recurrence. Twenty-one (84%) had > or =1 adverse event. Eight had permanent hypoparathyroidism (PH), six permanent recurrent nerve paralysis (PRNP) and two Horner's syndrome. Risk factors for PH and PRNP were total thyroidectomy with lymph node dissection (RR: 6.45, P = 0.015) and recurrent nerve tumour encasement (RR: 8.00, P = 0.001), respectively. Other adverse events were fatigue (n = 5), scar problems (n = 4) and chronic myeloid leukaemia (n = 1). These results emphasise the need to improve treatment strategies.
References
Jul 1, 1992·World Journal of Surgery·J K HarnessA Fukuuchi
Dec 1, 1992·Toxicology Letters·E D Williams
Aug 7, 1991·Journal of the National Cancer Institute·L E HolmL G Larsson
Dec 1, 1995·Mutation Research·E D Williams
Jan 1, 1997·The Laryngoscope·A WirtschafterJ L Rothstein
Dec 24, 1997·Leukemia & Lymphoma·F AlfiarJ H Lipton
Jan 29, 1998·The New England Journal of Medicine·M J Schlumberger
Feb 19, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·R FeinmesserA Noyek
Apr 29, 1998·The Journal of Clinical Endocrinology and Metabolism·C A SpencerJ T Nicoloff
Aug 6, 1998·Annals of Hematology·L LaurentiG Leone
Jul 18, 2000·Cancer·S A HundahlS Hölzer
Aug 22, 2000·European Journal of Nuclear Medicine·B JarzabZ Puch
Jun 18, 2002·The Lancet Oncology·Kirsten B MoysichArthur M Michalek
Sep 13, 2002·Thyroid : Official Journal of the American Thyroid Association·Wellington Hung, Nicholas J Sarlis
Dec 20, 2002·Thyroid : Official Journal of the American Thyroid Association·Gregory W Randolph, Gilbert H Daniels
Feb 28, 2003·Surgery·Oliver ThomuschHenning Dralle
Nov 7, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·E ErdemH Alagöl
Citations
Sep 16, 2005·The New England Journal of Medicine·Francis D Moore, Robert G Dluhy
Mar 23, 2006·Annals of Surgery·Yuri E DemidchikShunichi Yamashita
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen E KinahanKevin R Krull
Sep 25, 2009·Annals of Surgical Oncology·Nobuyuki WadaKoichi Ito
Feb 9, 2012·Journal of Pediatric Endocrinology & Metabolism : JPEM·Leilei Yuan, Jigang Yang
May 6, 2014·International Journal of Pediatric Otorhinolaryngology·Jaromír AstlJan Betka
Jul 2, 2014·Nature Reviews. Endocrinology·Markus LusterFrederik A Verburg
Sep 10, 2011·Journal of Thyroid Research·Fernanda VaismanMario Vaisman
May 23, 2009·Seminars in Oncology·Anita K YingSteven G Waguespack
Mar 26, 2015·Journal of Pediatric Surgery·Eva StokhuijzenA S Paul van Trotsenburg
Jun 1, 2005·Pediatric Blood & Cancer·Maura MassiminoUNKNOWN Thyroid Cancer Study Group of the Istituto Nazionale Tumori of Milan, Italy
Mar 25, 2015·World Journal of Surgery·Kiminori SuginoKoichi Ito
Jun 14, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Frederik A VerburgChristoph Reiners
Dec 30, 2014·Cancer Treatment Reviews·S C ClementH M van Santen
Sep 25, 2007·Arquivos brasileiros de endocrinologia e metabologia·Yuri E DemidchikShunichi Yamashita
Mar 4, 2020·The Cochrane Database of Systematic Reviews·Sylvia van DeurenJacqueline Loonen
Dec 22, 2016·The Journal of Clinical Endocrinology and Metabolism·Marloes NiesGianni Bocca
May 23, 2020·World Journal of Surgery·Kwangsoon KimWoong Youn Chung
Nov 21, 2017·Hormone Research in Pædiatrics·Bernadette L DekkerUNKNOWN European Initiative on Collaboration on Paediatric Thyroid Cancer
Jan 19, 2013·Endocrine Journal·Keisuke EnomotoShiro Noguchi
Nov 8, 2015·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Khalid Hussain Al-QahtaniWafa AlShakweer
Oct 8, 2020·Pediatric Radiology·Hedieh Khalatbari, Gisele E Ishak
Oct 31, 2020·Cancers·Aline Rangel-PozzoJanete M Cerutti
Aug 26, 2020·Journal of Pediatric Surgery·Mechteld C de JongTom R Kurzawinski
Apr 27, 2021·Pediatric Blood & Cancer·Priyakumari ThankamonyPradeep Veeramoni Iyer Mriduladevi