Frequent Application of the New Gelatin-Collagen Nonwoven Accelerates Wound Healing

Advances in Skin & Wound Care
Jennifer L SchieferAfshin Rahmanian-Schwarz

Abstract

Mortality after chronic wounds is high. Thus, proper and effective therapy is of critical importance. Adult mammalian skin cannot regenerate spontaneously. It heals under scar formation in a process of repair. In general, wound closure is achieved through a combination of contraction, scar formation, and regeneration. To enhance wound healing, research groups are continuously inventing and evaluating novel skin replacement products. A single application of a new gelatin-collagen nonwoven accelerates wound closure of full-thickness skin defects. Therefore, the authors' objective was to evaluate the effect of a higher application frequency of the nonwoven on wound closure in a minipig model. Four full-thickness skin defects were created surgically on the dorsum of 12 Göttingen minipigs. Next, 3 wounds were treated randomly with a novel gelatin-collagen nonwoven in different thicknesses, while the fourth wound was left untreated and served as the control wound. Moreover, 6 minipigs achieved multiple applications of the wound dressing. During the experimental period of 21 days, a close-up photographic documentation was performed. Finally, the areas of the initial wounds were excised and examined histologically. More frequent applic...Continue Reading

References

Jul 29, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M H QvistS Frokjaer
Feb 6, 2002·Clinics in Plastic Surgery·Ryan A Stanton, David A Billmire
Jul 19, 2005·Clinics in Dermatology·Andrea AndreassiCarlo D'Aniello
Jul 19, 2005·Clinics in Dermatology·Dorothy M Supp, Steven T Boyce
Feb 4, 2006·BMJ : British Medical Journal·Joseph E GreyKeith G Harding
Apr 22, 2006·BMJ : British Medical Journal·Stuart EnochKeith G Harding
Jul 26, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Xiaobing FuZhiyong Sheng
Oct 30, 2007·Journal of Pharmaceutical Sciences·Joshua S BoatengGillian M Eccleston
Jan 29, 2008·Journal of the American Academy of Dermatology·Margaret A FonderAdam J Mamelak
Apr 24, 2010·International Journal of Oral and Maxillofacial Surgery·S T BeckerH Terheyden
Dec 25, 2012·Tissue Engineering. Part a·Shani ShiloOded Shoseyov
Jan 30, 2013·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Crystal HolmesBlaise R Boles
Feb 19, 2013·Advanced Healthcare Materials·Daniel J GilmartinDavid L Becker

❮ Previous
Next ❯

Citations

Jan 25, 2017·Journal of Functional Biomaterials·Alessandra L MooreMichael T Longaker
Dec 7, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Giuseppe TronciDavid J Wood
Mar 30, 2018·Journal of Burn Care & Research : Official Publication of the American Burn Association·Marc Nicolai BuschePeter Maria Vogt
Dec 7, 2020·Burns : Journal of the International Society for Burn Injuries·Jan-Ole BaurWiebke Eisler
Jan 25, 2021·International Journal of Pharmaceutics·Muhammad Maaz ArifMuhammad Arif Butt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Mariane AltomareAndréa Monte-Alto-Costa
© 2022 Meta ULC. All rights reserved