Frequent BCOR aberrations in extranodal NK/T-Cell lymphoma, nasal type

Genes, Chromosomes & Cancer
Akito DobashiKengo Takeuchi

Abstract

Extranodal natural killer/T cell lymphoma (ENKTL) is a rare subtype of lymphoma. Recurrent mutations in the JAK-STAT pathway, recently reported in ENKTL cases, are interesting in terms of both pathogenesis and inhibitor therapy. However, the frequencies of these mutations are low and variable among reports, and other pathognomonic mutations in ENKTL remain to be elucidated. In the present study, targeted capture sequencing of 602 cancer-related genes from 25 frozen ENKTL samples was performed, 11 of which were matched to normal samples. Several recurrent somatic mutations involving BCOR (32%), TP53 (16%), DDX3X (12%), FAT4 (8%), NRAS (8%), MLL3 (12%), and MIR17HG (8%) were identified. The pattern of BCOR aberrations (1 nonsense and 5 frame-shift mutations, a mutation leading to a splicing error, and gene loss) suggested that loss of function of BCOR was the functionally important outcome of such changes. The literature was reviewed and the public data on BCOR aberrations was reanalyzed and it was found that the aberrations were frequently found in myeloid neoplasms, but, interestingly, were highly specific to ENKTL among lymphoid malignancies. Given the high frequency and pattern of aberration, BCOR is likely to play an importa...Continue Reading

References

Aug 1, 1994·The Journal of Experimental Medicine·M J SánchezJ H Phillips
May 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S ImashukuS Hibi
Jan 26, 2006·Blood·Ulrike BacherSusanne Schnittger
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie VoseUNKNOWN International T-Cell Lymphoma Project
Oct 7, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Motoko YamaguchiKazuo Oshimi
Dec 22, 2010·Blood·Bartosz GrzywaczMichael R Verneris
Oct 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Motoko YamaguchiRitsuro Suzuki
Jan 3, 2012·Haematologica·Enrico TiacciBrunangelo Falini
Mar 6, 2012·Nature Genetics·Gaëlle PierronOlivier Delattre
Jun 19, 2012·Cancer Discovery·Ghee Chong KooSoon Thye Lim
Feb 12, 2013·Nature Biotechnology·Kristian CibulskisGad Getz
Jul 3, 2013·Leukemia & Lymphoma·Hiroshi KimuraMasao Seto
Jan 15, 2014·Nature Genetics·Mamiko Sakata-YanagimotoShigeru Chiba
Feb 12, 2014·Molecular Cancer Research : MCR·Yukiya YamamotoNobuhiko Emi
Jul 10, 2014·Blood·Swapna ThotaJaroslaw P Maciejewski
Aug 1, 2014·Nature·UNKNOWN Cancer Genome Atlas Research Network
Aug 26, 2014·Nature Genetics·Yi-Bo GaoJie He
Aug 28, 2014·British Journal of Haematology·Bettina R BonnBirgit Burkhardt
Oct 10, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Andre L MoreiraMichael F Berger
Jan 1, 2015·Blood·R Coleman LindsleyBenjamin L Ebert
Jan 15, 2015·Nature Communications·Can KüçükWing C Chan
Jun 23, 2015·Nature Genetics·Hitomi Ueno-YokohataNobutaka Kiyokawa

❮ Previous
Next ❯

Citations

Sep 16, 2016·The American Journal of Surgical Pathology·Lien N HoangSarah Chiang
Dec 17, 2016·Journal of Clinical and Experimental Hematopathology : JCEH·Akito Dobashi
May 5, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Esra BaytakCan Küçük
Apr 14, 2017·Current Opinion in Hematology·Weicheng RenQiang Pan-Hammarström
Jul 7, 2017·Journal of Clinical and Experimental Hematopathology : JCEH·Motoko Yamaguchi, Kana Miyazaki
Mar 10, 2018·Pathogens·Stefan D DojcinovLeticia Quintanilla-Martinez
Dec 2, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natasha LewisSarah Chiang
Apr 19, 2018·Blood·John S Van ArnamKojo S J Elenitoba-Johnson
Aug 23, 2017·The Journal of Experimental Medicine·Tomoyuki TanakaAtsushi Iwama
Jun 1, 2019·Epigenomics·Annalisa AstolfiAndrea Pession
Jun 13, 2019·Hematological Oncology·Jie Xiong, Weili Zhao
Sep 19, 2019·Nature Communications·Zhaoming LiMingzhi Zhang
Nov 20, 2019·Current Hematologic Malignancy Reports·Geoffrey Shouse, Liana Nikolaenko
Dec 18, 2019·Reviews in Medical Virology·Takayuki MurataHiroshi Kimura
Dec 12, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ivonne A Montes-MojarroLeticia Quintanilla-Martinez
Jan 1, 2019·Uirusu·Hiroshi Kimura, Yusuke Okuno
Jul 4, 2018·International Journal of Molecular Sciences·Sanjay de MelSiok-Bian Ng
Dec 6, 2018·Journal of Hematology & Oncology·Jie Xiong, Wei-Li Zhao
Jul 6, 2018·Human Genetics·Nicola RaggeNicolas Chassaing
Mar 17, 2019·Journal of Hematology & Oncology·Nagavalli SomasundaramSoon Thye Lim
Jan 22, 2019·Frontiers in Pediatrics·Hiroshi Kimura, Shigeyoshi Fujiwara
May 30, 2019·Frontiers in Oncology·Qingqing CaiKen H Young
Apr 3, 2019·Journal of Hematology & Oncology·Sanjay de MelSiok-Bian Ng
Mar 5, 2020·Therapeutic Advances in Medical Oncology·Can KüçükHua You
May 26, 2017·Journal of Pathology and Translational Medicine·Yoon Kyung JeonUNKNOWN Molecular Pathology Study Group of Korean Society of Pathologists
Jan 26, 2021·Critical Reviews in Oncology/hematology·Celeste Sánchez-RomeroRomán Carlos
Jan 1, 2020·Seminars in Diagnostic Pathology·Ivonne A Montes-MojarroLeticia Quintanilla-Martinez
Dec 31, 2020·International Journal of Molecular Sciences·Satoshi Kaito, Atsushi Iwama
Apr 4, 2021·Cancers·Ivonne A Montes-MojarroLeticia Quintanilla-Martinez
May 22, 2021·Seminars in Diagnostic Pathology·Swee-Shan Hue SusanSoo-Yong Tan
Aug 1, 2021·Virchows Archiv : an International Journal of Pathology·Mauro VasellaBeata Bode-Lesniewska

❮ Previous
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