Frequent detection of androgen receptors in spindle cell lipomas: an explanation for this lesion's male predominance?

Archives of Pathology & Laboratory Medicine
Sajjad SyedJohn J Brooks

Abstract

Spindle cell lipoma (SCL) is a tumor with marked male predilection. We discovered one SCL that exhibited strong immunoreactivity for androgen receptors (ARs) in the spindle cells. The hypothesis was that ARs in SCLs would not be rare and that all or nearly all SCLs would be AR positive, perhaps explaining its male predominance. Twenty-eight cases of SCL (22 men, 6 women) and a control group of 20 conventional lipomas (10 men, 10 women) were stained with monoclonal AR antibody (1: 150; Dako, Carpinteria, Calif) using the Ventana Discovery. Only nuclear reactivity was considered positive, as noted in prostate controls. Cell types (fat, spindle cells) and extent of staining were recorded as rare, considered negative, focal (1+), or diffuse (2+/3+). All 22 cases of SCL in men were positive for ARs. Twenty showed diffuse (2+/3+) reactivity mainly in the spindle cells. Of the 6 SCLs in women, 1 was AR negative, 1 showed a 3+ reaction in the spindle cells, and 4 had weak (1+) staining of spindle cells. Overall, 96% of SCLs were AR positive, including 83% of SCLs in women. Seventy percent of conventional lipomas showed positive staining in fat, but only 2 showed 2+ staining. In the rest, staining was rare or weak (1+). Nearly all SCLs ...Continue Reading

References

Nov 1, 1975·Cancer·F M Enzinger, D A Harvey
Aug 1, 1987·Histopathology·C D Fletcher, E Martin-Bates
Jul 1, 1983·Histopathology·J G AzzopardiR Salm
Jun 18, 1996·Molecular and Cellular Endocrinology·C M Wilson, M J McPhaul
Jan 9, 1998·The American Journal of Surgical Pathology·J C Fanburg-SmithS W Weiss
Jun 5, 1998·The American Journal of Physiology·M N DieudonneY Giudicelli
Aug 2, 2003·Molecular and Cellular Endocrinology·Hannelore HeemersJohannes V Swinnen
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Karen L Herbst, Shalender Bhasin
Oct 18, 2007·Journal of the American Academy of Dermatology·Sajjad P SyedJohn J Brooks

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Citations

Nov 3, 2009·The Journal of Craniofacial Surgery·Giada VecchioGaetano Magro
Feb 4, 2009·Journal of Cutaneous Pathology·Rajni V MandalG Petur Nielsen
Apr 1, 2009·Journal of Bronchology & Interventional Pulmonology·Lama SakrAndrew R Haas
May 29, 2010·International Journal of Otolaryngology·Oladejo OlaleyeDavid Mitchell
Nov 24, 2021·International Journal of Surgical Pathology·Jiro IchikawaHirotaka Haro

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