PMID: 7546909Jul 1, 1995Paper

Frequent detection of antibodies against HTLV antigens in patients with AIDS-related non-Hodgkin lymphoma

AIDS Research and Human Retroviruses
Gianguglielmo ZehenderMassimo Galli

Abstract

We studied the prevalence of anti-HTLV-I/II antibodies in 22 patients with AIDS-related non-Hodgkin lymphoma (NHL), 453 HIV-1-infected patients without lymphoma (194 of whom were diagnosed as having AIDS), and 6 HIV-1-positive and 75 HIV-1-negative patients with Hodgkin lymphoma. The frequency of serological reactivity against HTLV antigens was significantly higher in the AIDS patients with lymphoma than in those without (8 of 22, 36.4% vs. 20 of 194, 10.3%-p = 0.0027). One of the HIV-1-positive and none of the HIV-1-negative patients with Hodgkin lymphoma showed anti-HTLV-I/II reactivity. Four of the eight seropositive NHL patients showed antibodies directed against HTLV-II recombinant antigens when tested for serological discrimination in a Western blot assay. A PCR study of PBMCs from the only patient with NHL still alive at the time of the study showed HTLV-II-specific sequences in the genomic DNA. These data suggest that HTLV-II or a closely homologous retrovirus infects a high proportion of patients with AIDS-associated NHL.

References

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Citations

Dec 24, 1997·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C TusetV Soriano
Dec 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sylvina BassaniJose M Benito
May 20, 1996·AIDS Research and Human Retroviruses·G ZehenderM Galli
Apr 30, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·M A BeilkeD G Vinson
Mar 31, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Carlos ToroUNKNOWN HTLV Spanish Study Group

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